J.D. believes he may have finally found a mentor in Dr. Kevin Casey, a surgeon with obsessive-compulsive disorder, and it turns out that Dr. Cox has always been jealous of the guy. Meanwhile, the Janitor and his new assistant help Kelso out with a garbage problem.
A high school student is found murdered, and it appears she's the victim of incest.
A man armed with a bomb walks into the station house and handcuffs himself to McDowell; unless the detectives release a Russian mobster from jail in one hour, the bomb will detonate.
Ephram gets the wrong idea when Madison tells him her roommate is going to be out of town, but the misunderstanding leads to an intimate moment for the couple. In other matters of the heart, Amy decides she's ready to have sex with Tommy, so she works up the courage to ask Dr. Brown to write her a prescription for birth control pills, and Andy makes the important decision to talk to Ephram and Delia about Linda spending the night at their house.
A slow burn in the Everglades that turns on itself yields a body different than the one Eric and Alexx were brought out for, and endangers their lives; Horatio thinks he's found a sexual predator, but now he must prove it.
Gay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
Bradfield is in panic as someone preys on its most vulnerable—its hospital patients. Carol must juggle how to warn the public, and how to keep a predatory MI5 official at bay. The only way out is to solve the case fast—but there is very little to go on, even for Tony.
A sportscaster must take on the responsibility of being a full-time dad when his teenage daughter moves in with him.
Mona and Dee Dee are half-sisters with the same father who didn't really know each other when they were little and are complete opposites, but as adults they live in the same apartment building and at least try to bond.
A newly single Joan tells Toni she's happy spending Valentine's Day alone, but Toni is not convinced; Williams gets Lynn to spy on a possible soul mate; Joan runs into an ex-boyfriend.
One of Harper's experiments goes awry, and Dylan ends up in an alternate reality.
Against Alan's judgment, Charlie falls for a seemingly crazy woman named Frankie.
Fed up with his wife's constant lateness, Ray leaves Debra at home rather than take her to the ESPY Awards. While Debra seethes over Ray's actions, Marie and Amy get into a heated debate with Frank and Robert when they air their own grievances about their wives' blatant disregard for the time.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
The lives and relationships of a group of siblings and their estranged father Frank Gallagher on a rough Manchester estate.
A fugitive geneticist and four of his creations search for others of their kind while attempting to stay a step ahead of a morally ambiguous government agent.
Manny and Craig's pregnancy is outed by the furious Ashley to the whole school during lunch. Their failed practice to take care of Spike's baby convinces Manny, but not Craig, that, at 14, she is not ready for motherhood.