Dr. Ron informs Susan that she needs a splenectomy. Gabrielle and her arch-enemy Sister Mary Bernard finally face off in church. Also, Tom decides to apply for an empty position at Lynette's job, which leads to the arousal of past issues in their marriage. Lastly, Matthew and Danielle's relationship is found out by both their mothers, which leads to big repercussions later on for Bree and her past secret with Andrew last year.
Angel puts his own life at risk when an American is held hostage. Meanwhile, Sergio and Anna's relationship continues to grow, and Venessa tries to make up for her past.
Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task to expel a discharged and defiant woman from the hospital. Alex learns his fate after re-taking his medical exams. At the same time Izzie is trying to stop Alex from making stupid decisions when a patient that doesn't speak English is lied to by her coach. George, Cristina, and Alex compete in a hot dog eating competition.
After learning that God's greatest gift is life, Orel recruits his friend Doughy to help protect that gift. A library book, a graveyard full of dead townsfolk, and Orel's convictions spell trouble for the population of Moralton.
Grandad opens "The Itis", the only soul food restaurant in Woodcrest. White people didn't expect it. They also didn't expect high cholesterol, heart disease, and obesity.
Phoebe, in an attempt to move on with her own life, signs a lease for a new apartment, and Paige considers moving in with Henry. However the sisters are forced to remain under the same roof when a demon shrinks them and traps them in a replica dollhouse of the Manor.
Bartlet must deal with the possiblity of a nuclear explosion in California, Kate is keeping a careful watch on the election in Kazakhstan and China's response, Will is acting as the government's voice this week, and Josh is trying to keep his political version of Tourette's in check.
Shane opens her own styling business, and Bette loses her position as the sole provider for the family, forcing Tina to take up a job under Helena. Now back in L.A., Jenny introduces Moira to her surprised friends. Dana and Lara make plans to visit France while Alice still obsesses over Dana. Meanwhile, Kit is surprised by The Planet's new manager who wants to make some drastic changes to the place.
Logan and Barek investigate after a body is found in the ocean, having fallen from an airline wheelwell. They soon discover that she is just one in a long line of prostitutes to be beaten and murdered. Their investigation leads them to a nervous airline employee, but they just don't feel he has the courage or the violent nature to commit these crimes on his own. A family connection leads them to a second suspect, with a history of both being abused and being the abuser.
Jenny steals a music player while in disguise as "Ruby Rocket," and an angry crowd forces Jenny to battle her alter-ego.
August 1942. Foyle investigates the a mysterious disease affecting local farm animals and looks into the arrest of a pacifist accused of stabbing a war hero.
Starr goes goth, and Jude goes goth as well to impress her. Meanwhile, the rest of the gang visits the movie theatre during a power outage at the mall.
Jordan and Woody investigate the death of two soldiers. One was killed in Iraq, the other has been killed in Boston. Dr. Macy confronts his daughter over her choice in boyfriends and a possible addiction to drugs. Jordan discovers a secret J.D. is keeping.
Ben must rescue his aunt and grandfather when they are held hostage by shape-shifting aliens.
Taking numbers instead of names, five extraordinary 10-year-olds form a covert team called the Kids Next Door with one dedicated mission: to free all children from the tyrannical rule of adults.
Kibre and Gaffney are forced to prosecute a doorman who killed a homeless man while he attacked a frightened woman who lived in the building. After the woman tells the grand jury that she's been stalked for four months, thinking it was the homeless man, Kibre and Gaffney look into who the stalker was.
Substitute Teachers:Ned helps Mr. Weiner, a favorite substitute from Elementary School get in touch with his middle school side. Cookie poses as a substitute teacher. Moze becomes bad-girl material and misbehaves to the new science substitutes. The New Kid: Ned tries to help a new kid, Bernice, at James K. Polk. Gordy compete against a new janitor that could take over his spot.
With a Royal visit planned for Wellminster Cathedral, Rosemary and Laura find themselves hired to help restore an old monastery garden at the cathedral in time for the visit, although not everyone is pleased by their presence. No sooner have they started, the body of the local custodian's step-daughter, Trish, is found by the gardeners, who soon uncover secrets within the cathedral's tight-knit community, before a skeleton is found within the garden's old well...
Red uses some unexpected cash to put on an Air Show but when he's denied a permit, he tries to fool the crowd with model airplanes. Ed Frid brings a black bear to Talking Animals. Red uses a water wheel to power a car. Bill has an adventure with ropes. Mike tries to guess the word 'back' in the word game. Red invents a car deodorizer and a way to stop your guests from using too much hot water.
Billy, Mandy and Grim visit Mighty Moe, an old man who has discovered the secret to add extra years to his lifespan: a good diet and exercise. Mighty Moe decides to publish his secret in a book, and Grim needs to stop him by offering junk food.