After an actress is found dead in her apartment, Green and Cassady attempt to prove that her death was not a suicide.
Lonely and bored, Shawn convinces Juliet to give him a shot with a case involving a missing tennis star, but first he has to spring an unwilling Gus from a corporate retreat.
Melinda accompanies Delia to the local jewelry store so she can get her newly refurbished engagement ring. An armed robbery occurs while they are in the jewelers. Later, the ghost of jewelry salesman visits Melinda and she must help him make things right again.
Jimmy loses at a pub quiz and he has asked Diana to help out to win the pub quiz, and Diana goes along with Jimmy for a fun night out with her ex-husband. Molly stays out for the night with a friend but she gets back in the early hours of this morning.
As Stephanie and the others go to school, Robbie comes up with a plan to prevent the kids from learning, disguising himself as a teacher, and not teaching them lessons.
One of David's closest friends is called into question after a man dies while boxing with him. When it turns out this is not the first time such an event has happened, things look even worse. Charlie is busy practicing what little he knows about poker, so he can take Larry's spot in a tournament.
Meena and Newt plan to go skiing in South America and Cory wants to go. However, Stickler, who is also coming (uninvited), uses CIA technology to destroy Cory's ATM card. In order to get the needed money, Cory gives secret tours of the white house in which they see Sophie. However, when Sophie finds out she isn't going skiing, she steals Cory's money and runs off. Meanwhile, the President is having trouble sleeping and is keeping Victor up during the night.
Sam's old love awakes from a 20-year coma. This makes Delinda the casino host for a whale visiting town whith his three wives. Things complicate when Mike falls in love with one of the wives and Danny gets jealous about the intentions of the whale toward Delinda. Ed tries to replace his housekeeper when Jillian is out of town.
Kelly, a member of the Solana staff tells Donald and Jacqueline that she is engaged to the sexy waiter Mateo. Maeto is then seen flirting with Kate.Having now got over the shock of Chantelle having a baby, Janice begins to bond with her daughter.Geoff and his mother do a duet at the karaoke.
Once he unseals a package sent to him through the mail, Grissom is floored when he finds a miniature crime scene inside. The finding is entirely more perplexing since the successive killer accountable for earlier related miniature crimes is now deceased. Grissom plows to examine the miniature and discover the actual location, when the investigation makes it clear the murder showed has yet to happen, but is probably going to happen soon.
Daniel reconnects with Grace Chin, a girl he once stood up for a date in college, and who is now New York City's top lawyer. Meanwhile, Betty befriends Charlie, an out-of-towner she meets at the Mode cafeteria, whom she later discovers to be Henry's girlfriend.
Kovac and Gates find themselves with a moral dilemma when a woman comes into the ER with acute liver failure; Neela finds herself questioning what is right when Manish decides to give up a kidney to a complete stranger. Meanwhile, Ray fights to get to the bottom of a cheerleaders accidental fall; Abby gets a prediction for her future; and Alex's troubles continue to intrude on Sam's work life.
As shocked as she is to be called the c-word by Lutz, Liz is more horrified to realize he may be right. Meanwhile, Jack brings Tracy to a charity golf event to get closer to the chairman, however his plan backfires when Tracy acts too much like his uncensored self.
In the immediate aftermath of a violent earthquake that rocks Newport, everyone struggles to stay together and keep their spirits up. Sandy and Kristen are stranded at the local shopping center where Kristen has an accident. Across town, Julie and Kaitlin are stranded in a demolished ice cream parlor on the pier with a pitiful worker of the place. Meanwhile, Ryan is seriously wounded with a piece of glass in his side, but keeps the news from Taylor to avoid panicking her. Seth soon learns of Ryan's condition and attempts to drive him to safety while Summer and Taylor search the ruins of the Roberts' house for Summer's missing rabbit, leading to Taylor having a confrontation with her mother.
Earl wants to use his birthday to look back on all the good he's done over the past year, but at his party, everyone seems to want to talk about his past misdeeds instead.
A Croatian Doctor comes to Sacred Heart, only to find out that he has to redo his Internship there. J.D. shows symptoms of 'Vasovagal Syncope', a condition that causes fainting and blackouts. Turk and Elliot argue over whose turn it is to take care of him, whilst Carla tries out her new excuse "I have a baby" and the Janitor takes a vacation.
Happy-go-lucky party animal Chris wakes up one morning to find his mum's gone away for a few days and left him a grand. But what do you do after you've thrown a party to end all parties and blown all the money?
Meredith is still underwater, but nobody seems to notice. Her worsening condition makes her rescuing an urgent matter. Derek finds her coat on a man she had helped, and starts looking for her and, much to his shock, the little girl Meredith took care of suggests that she is in the water. Derek saves her, but she is almost dead, due to hypothermia. Izzie has to perform brain surgery on a man stuck between cars, as he begins to experience seizures. She drills holes into his head, perforates his skull and ultimately saves his life before he is rescued and transferred to Seattle Grace Hospital. George lies to the woman whose son he had been looking for, in order to get to surgery, but still doesn't have any luck in locating him. Alex finds no hope in searching for the pregnant Jane Doe's family as she undergoes surgery. The interns find out about Meredith's situation and express their hopelessness. She wakes up in what appears to be limbo and meets her deceased acquaintances.
A boy named Tobias was blinded by the meteor shower but given the ability to identify other meteor freaks. Lex is using Tobias to locate other people with abilities so that he can perform experiments on them. Lana learns of Tobias and is fearful that he will name Clark as a freak, so she offers him a cornea transplant to keep him quiet. But Tobias has some surprising news.