When Jonsey starts working at The Penalty Box and doing a much better job at sales than Jen, Jen is furious. The two start competing for commissions and the customers become the spoils of war. The competition extends to their personal lives when Jonsey makes a comment at lunch about how ""guys are just naturally better at some things"" and Nikki, Jen and Caitlin take offence. Soon the lines between the sexes are drawn and an all out all-over-the-mall battle of the sexes begins, culminating in the ultimate dare of a lifetime. Meanwhile, Jude starts a Dude Daycare at The Mall and ends up with more kids – and trouble – than he can handle. Will the guys have to ask the girls for help after all?
Meredith realizes that she must take on a lot more responsibility when she is told that her mother needs to sign over all of her assets to her. As Izzie prepares to have a party for her boyfriend Hank (the scale of which is unknown to Meredith), Meredith has her first heart surgery. During the surgery she fears that she has fallen asleep and damaged the patient's heart. Meanwhile, Cristina and Burke hit it off. At the party, Meredith and Derek get caught together by Dr. Bailey.
Wolcott reports his gold-claim acquisitions to his employer, George Hearst, and Nuttall shows off his new bicycle. Meanwhile, Miss Isringhausen reaches an agreement with Swearengen, who also meets with Bullock to discuss alternatives to annexation.
Reese befriends a pack of troublesome stray dogs; Dewey feels conflicted when he starts seeing another mother-figure; Hal unwittingly becomes a motivational speaker.
Cory and Trevor start to work for Julian. The boys steal drugs from Cyrus and hatch a plan to hide it all until they can find a buyer.
A lesbian cruise in the Caribbean proves eventful for Dana, Alice, Shane, Jenny and Carmen. Bette and Kit struggle to reconcile with their estranged father, Melvin, during his visit.
The sisters scramble to recover Pandora's Box when it falls into the hands of a shapeshifting demon who intends to open it and fill the world with all of its sorrows. Meanwhile, Paige's Whitelighter side rises to the surface, when she begins hearing calls from the Elders, and Leo and Piper clash over parenting issues - namely raising magical children.
The Shredder is leaving Earth in a spaceship of his own construction intent upon wreaking havoc on the Utroms and the galaxy. But he's taken on some unwanted passengers and they're not about to let the Shredder get away.
The Warriors travel to Tokyo in search of the Zing Zom-Bone, a Shen-Gong-Wu that can turn anyone into a zombie-like state. Once there, they meet up with Kimiko's father, who is the owner of a major video game company. Unbeknowst to the Warriors, Kimiko's father brings in Pandabubba as his new business partner, not knowing he's in fact a criminal. Jack finds the Zing Zom-Bone first and brings it to Pandabubba who uses it on the company's workers and Kimiko's father to do his bidding. Can the Warriors stop Pandabubba a second time?
Upon seeing the rare Heylin comet circling the Earth, Master Fung orders the Warriors to not use any Shen-Gong-Wu for three days. The comet makes the Wu have a mind of their own if used by anyone. Wuya sees this as an opportunity to tempt the Warriors to use the Wu. After using the Golden Tiger Claws and Sword of the Storm to save his hometown from a volcano eruption caused by Jack and Wuya, Raimundo literally becomes attached to the Claws. The Shen-Gong-Wu begin to have a mind of their own and attach to Raimundo, making him 'monster-like'. Once Raimundo loses all his self control, Wuya plans to take over his body and finally carry out her plans to rule the world.
As the race for the Speed Planet Cup continues, Hot Shot teaches Override the Autobots' code of honour, while Overhaul faces Scourge on the Jungle Planet.
Time is running out for the Doctor as Downing Street announces mankind's first Interplanetary War.
A truck carrying radioactive material is stolen, and the thieves threaten to set off a dirty bomb in L.A. in 12 hours if they aren't paid $20 million. While Don attempts to track down the truck, Charlie tries to come up with the most likely location where the bomb may be detonated to inflict the most damage to the population.
The evacuation of Seefra-5 is at risk when a religious sect decides to stay on the planet.
Zack and Max compete in a dance contest. Cody learns how to do magic. Zack injures himself, and Cody has to take his place in the dance finals. Maddie becomes London's servant after London lends her money.
Melanie learns that monkeys belong in the rainforest when she encounters one.
Finney and Davis are seriously injured in a car accident during a traffic jam, which was caused by a man trying to kill two people, and he succeeds. Emily's life is in danger when she falls in with the wrong crowd. Carlos buys an engagement ring for Holly.
Kibre tries a man who got away with murder, and she is desperate to convict him.