After a near-death experience, Jimmy finds a list he made of everything he ever wanted to do in life but didn't -- and plans to do everything on it while he still can.
Brennan battles with a Guardian of the Prophecy to stop the late mutant Ashlocke's plan from beyond the grave of world domination.
The death of a man from Beka's past named Weslow, sends the crew in search of an archive that can let Beka relive some of her childhood experiences so that she may make sense of Weslow's dying words.
When Amy accompanies Ephram to his Julliard audition in Boulder, a romantic moment leads her to confess her newfound feelings for him. Meanwhile, Andy struggles to convince his mentor Dr. Douglas (guest-star Philip Baker Hall) that he needs even riskier brain surgery than originally thought and that Andy is the man to do it. Dr. Abbott faces losing his medical practice after it appears no company will insure him. Lastly, Bright decides not to attend his graduation ceremony, much to the disappointment of his family.
After a small plane crashes at a Miami beach and the pilot dies, Horatio finds remnants at the crash site of chemical used in making cocaine, and it seems that the victim's business partner may have sabotaged the aircraft. However, when evidence suggests that the pilot may have died before the crash, the team investigates the victim's neighbors – all wealthy residents of a secluded cul-de-sac where lust, jealousy and greed are dangerous motives for murder.
William is made a senior partner in the law firm. He is thrilled about this, as is Maya, who will now get a substantial raise. He brings a beautiful date to the party honoring his promotion. Joan comments that he now has everything he wants, but William still feels as though something is missing. He talks with Swedelson at a strip club. Swedelson says that William should not pursue a relationship with Joan and instead advises him to go after Sharon, who had earlier seemed to be sending William signals. However, William discovers that Sharon is involved with the building's security guard. He goes to Joan's house and tries to share his feelings with her, but backs down after she talks about thinking of him as her ""big brother."" Meanwhile, Toni, Maya and Lynn enjoy the benefits of an especially friendly masseuse.
When Robert informs Ray that Amy filled him in on some juicy gossip about him, Ray decides to get even with Debra by sharing some nasty secrets of his own.
Justin finds himself risking his life with the Pink Posse; Avoiding his friends, Ted finds work as a waiter; Vic decides to move in with Rodney, leaving Debbie alone.
Eugene considers an exciting new offer for his future... could this mean the end of the practice? Meanwhile, Jimmy is shaken by an ominous run-in with neighborhood lawyer Lenny Pescatore, as their turf war heats up, and Ellenor clashes with sexy and ruthless attorney Hannah Rose of Crane Poole & Schmidt.
Sue does some digging into Troy's past only to learn that Tory's brother Ben came back into his life. Sue and Jack head to the local gas station to tell Troy that his brother Ben will be a dinner guest Tory doesn't like the idea. Also Bobby continues to perform at The Black Dragon and stop The Scorpions (a Chinese gang) from delivering heroin to The Black Dragon. Troy gets to meet his brother's wife and his son who is deaf Troy figures that his brother just wants something from him because of his handicap. Troy is angry because his brother walked out on him as a little boy.
Ride Owner: Neil. 18 Year Old Male. Owner's Ride: 1974 Chevy "Luv" Truck. Neil's truck, the Mikado version, has looks that not even a mother could love. With a hunk-of-junk camper on its back and mismatched wheels, this Chevy is getting Neil anything but love. His ride's system, is actually a boom box. Xzibit and West Coast Customs is gonna put the love back into his "luv" truck. Xzibit is about to pimp his ride. Additions & Improvements: -Paint, true blue pearl with flames on the hood -Chrome rims -Neon lights -Xbox -7,000 watt system -The truck bed rises up to create a camper -Gift from X, some new camping gear Neil has officially been pimped. Final Look -Norrin Radd
Bobby joins his school academic team as the expert in pop culture, but the pressure gets to him.
Ashley Blake is coming to the movie theater for the premiere of her new movie. Helen wants Josh to do everything Ashley tells him. Then Drake helps him in order to get into the afterparty. When Ashley accidentally gets hit in the head with a bucket, the doctor comes and puts Ashley to sleep. Drake and Josh must find a way to get her to the premiere without making it look like she's asleep.
On a family fun day in the Park, Mr. Lahey plans to get his old supervisor job from Ricky. Bubbles wrestles under the alias, ""The Green Bastard"".
When Dewey's annual candy selling event for school comes up, he uses the excuse of "these bars help support america" to sell them. Malcolm and Stevie attempt a science experiment, and are shocked when Reese begs to help.
Malcolm convinces Dewey to do poorly on an I.Q. test, so that he won't become a ridiculed Krelboyne student. But Dewey does so badly that he is placed in a class for the emotionally disturbed. Hal and Craig compete in a dance competition.
The 1999 drowning death of a military academy's swim coach, which was originally ruled as accidental, is reinvestigated after the homicide division receives a note that suggests it was murder. Back at the office, Valens searches for Elisa after she goes missing.
With the aid of Katya Derevko and CIA imprisoned security systems designer Toni Cummings, Sydney and Vaughn attempt to track down Sloane and Nadia. But Lauren and Sark are also in hot pursuit of them in order to uncover the secrets of Rambaldi. Meanwhile, Vaughn's obsession with tracking down Lauren is beginning to consume him, Sydney and Vaughn turn the tables on an old foe, and Katya expresses her attraction to Jack.