Stephen asks Karl questions posed to guests on "Inside the Actors Studio, leading to a discussion of organ donation. From Karl's diary: A news report from India about an elephant who had a giant pair of slippers, and Karl's belief that scientists should give up trying to kill germs because it will only make them stronger and bigger.
When an animal rights activist working undercover at a farm goes missing, Allison befriends a pig that could hold the key to the woman's whereabouts. Also, Joe's special birthday gift from Marie leaves him wondering how she was able to obtain it.
When the ghost Melinda is trying to help suddenly turns up alive, she finds herself in the middle of a dangerous revenge plot and battling enemies she was unaware she had.
A motorcycle accident and a small plane crash provide new patients for the Alpha Team, while they wait to hear news about one of their own.
Ben gets an offer to star in his own video game, but the designer's real motives are part of a plan to destroy Ben.
When the school's superintendant fires Mr. Laritate because of Alex, Mr. Laritate gets a job at a western place. When the school hires a strict new principal, Alex transports Mr. Laritate back to the Old West in an attempt to show him that it's not what he thought it was and make him want to come back to Tribeca Prep.
An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient (guest star Demi Lovato) whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen -- which inevitably messes with Cristina's head.
The ladies bask in some fun in the sun when Ramona organizes a "renewal getaway." Still stung from her loss, Bethenny is comforted by the ladies---until Kelly kicks up some drama. Meanwhile, LuAnn tunes up in the Big Apple by recording a song in the studio.
The CSI team must investigate one of their own when Langston is accused by a former colleague of being part of the Dr. Jekyll murders, on part one of a two-part season finale of CSI.
Jack becomes even more entangled in his love triangle between Avery Jessup and Nancy Donovan, and he turns for advice to Liz, who is focusing on her own romantic problems. When Liz can't find a date to Floyd's wedding, she revisits her old boyfriends in hope that a spark will reignite. Meanwhile, Tracy continues his journey to earn his egot.
Mark continues his interrogation of Hellinger in a desperate attempt to find out when the next blackout will occur. Demetri must choose between helping Janis and Simon break into NLAP to stop the blackout from occurring, or turning the fugitive Simon in to the FBI. Elsewhere, Lloyd finds the common denominator that can help him solve the complex equation he was working on in his flashforward.
Leslie is disappointed when her new park plans are put on hold by a visit from two state auditors. April has plans for Andy at her birthday party, and Ann tries to piece together a romantic mystery.
Founder's Day has finally arrived, and everyone is busy with last-minute preparations for floats and fireworks. Stefan is uncomfortable with Damon's new attitude toward Elena, but Elena is more concerned about repairing her relationship with Jeremy. Jeremy is worried about Anna, but not sure he's on board with her latest plan for the future. While Caroline is enjoying her day as Queen of the celebration, she also tries to help Matt and Tyler get their friendship back on track. Finally, although Damon and Alaric do their best to stop him, Johnathan Gilbert sets a plan in motion that brings Founder's Day to an end amid chaos, destruction and death.
A series of shocking surprises await the crew when they discover a secret community living on a tropical island. Robert risks his life to save Bomber during a gunfight with drug runners, and Mike investigates claims of an illicit romance between two crew members.
On the eve of an important final exam in Spanish, everyone's grades are jeopardized when it is discovered that Señor Chang has a damaging secret.
Romantic sparks begin to fly when Patrick Jane and supposed psychic Kristina Frye cross paths again during the CBI investigation into the murder of a charismatic head of a non-profit organization that fights human trafficking.
When Walter discovers that Peter has traveled to the alternate universe, he and Olivia gather three cortexiphan children with the ability to transition safely between the two Earths.