Samantha is suspicious about Regina's action, which lead her to believe she is having an affair. But she's not alone. Todd is cheating on Chloe, who is none the wiser, with Samantha. Dena and Regina are contemplating opening up their own coffee shop.
Moz is a drug dealer and has very strange clientele who come and go from his flat.
Dani faces a tough decision: Noah or horse racing, and Matt and Kris find running the dude ranch difficult. Later, while searching for two missing children, Matt and Junior argue.
Allison has dreams that help Scanlon in his search to find out who killed a wealthy local drug dealer. Allison and Scanlon are dumbfounded when Allison's dreams lead them to a severely impaired man with a bullet stuck in his brain. Meanwhile, Joe's partnership with Meghan Doyle is put in jeopardy.
While Lo and Lauren enjoy living at the house, Audrina feels more and more left out. Meanwhile Stephanie thinks it's time to get rid of Spencer and Heidi prepares her next step in her career.
A man is murdered when someone drops a piece of slate off a bridge. The team tracks the slate to one of their own and Alexx's son becomes a suspect. Then to make matters worse Alexx finds him in a warehouse holding a bloody knife over his friend who happened to be the other suspect.
Brennan's father Max Keenan is on trial for the alleged murder of FBI Deputy Director Kirby. Everyone on the team, except for Brennan, is called as a witness for the prosecution during the trial. Brennan on the other hand is the forensics advisor for the defense, and she must rely on both her dedication to her family and her skill as an anthropologist to help free her father.
Georgina informs Serena that she can reveal a deep dark secret from Serena's past, but no one is prepared for what Georgina does next. Blair and Jenny's power struggle continues when each of them start spreading scandalous rumors about each other on Gossip Girl. Dan sees Jenny's new beau, Asher, cheating on her, but Jenny won't listen to him. Rufus goes to Lily for advice on how to handle Jenny's new behavior. Serena tries to confront Georgina, but she leaves before Serena has a chance. After this, Serena says that she and Georgina are not friends.
The rest of the gang fall for Sheldon's twin sister, and Leonard's plan to win her heart is derailed when Sheldon declares he'll be the one to decide who can date her.
Lucas investigates Dan's heart condition. Haley struggles with letting Dan into Jamie's life. Peyton also still struggles with her guilt over Lucas' breakup and Mouth finally gets the chance to be a sports anchor.
The crew of the Hammersley are joined by a federal agent and go in search of an illegal fishing boat. Whilst on board the Navy find evidence on the boat and find the fishing boat crew start to exhibit symptoms of bird flu. One crew member faces a gruesome operation, while the federal agent learns that blackmail can work both ways.
Barney gets a new wingman and Ted meets Stella's daughter.
House is convinced one of the actors on his favorite soap opera “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House’s assessment and do not believe there is anything wrong with him.
The power might be out but that doesn't stop host Alton Brown from breaking out the cast iron and using his hearth and his grill to whip up some very good eats. Recipes : Knead Not Sourdough Dutch Oven Cherry Clafouti Dutch Oven Hoecakes
Arcadia is plagued with evil, life-draining demons called Thanatos and a vast lack of Purifiers to exterminate them all. While attending school, Angelique attracts the eye of a man who intends to turn the tides to the people's favor. What lies within her is the key to Arcadia's survival.
A drug addict mother, who lost her son in an apartment fire in 2005, comes forth claiming she just saw the same child in the park.
Miley is almost struck by lightning which makes her and Jackson travel back in time to when their parents met.
After outing himself as an alien, Roger (in disguise) finagles his way into being appointed the CIA's chief alien hunter to take advantage of a lavish expense account--while coming up just short in attempts to catch himself. Meanwhile, Francine shocks her family by displaying a prejudice they never knew she had.