During a short film made by Odd and starring Sissi, Sissi seems to be possessed by a ghost. She does not act as expected, however. Instead, she starts speaking in some strange language, focusing on Jeremie as she does. She is taken to the infirmary as a result. Later on, she walks into Jeremie's room and writes some code on a piece of paper. Jeremie translates the code, revealing a message stating a desire to help. Sissi is sent to the hospital after this, forcing Odd and Yumi to go there and collect her. On a trip to Lyoko, Aelita and Ulrich discover a white tower. Xana isn't happy about the tower, and sends Megatanks to shut it down forcibly. At the same time, it activates a tower and possesses a nurse at the hospital to do the same to Sissi. Odd and Yumi are able to prevent the nurse from doing so. They bring Sissi to the factory to finish the message she started earlier. She manages to type most of it out before Xana succeeds in shutting down the white tower. After Xana's tower is shut down, Jeremie translates the message, revealing that Franz Hopper had activated the white tower.
Jeremie discovers five activated towers and gathers the group to take care of them. However, when they arrive at the factory, they find a man at the interface, deactivating the towers as if it were a simple matter to do so. When questioned, the man claims that he's none other than Franz Hopper. However, something seems off about this convenient arrival. Franz says that the scanners cause cell degeneration, and blames it and the destruction of his diary on Jeremie. With everyone except Aelita angry at him, Jeremie calls his father and asks to be withdrawn from Kadic in favor of a school for gifted students – but after he hangs up, while pondering his dilemma, he realizes that there is something inherently wrong with Franz's explanation.
Luke gets to know April. Rory tries to get the school newspaper published after the staff quits. All four Gilmores vent their frustrations.
Dean is contacted by his first love Cassie, an African-America girl, who asks him to come to Mississippi to investigate a string of racially motivated murders. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. Sam is stunned to see this new side of his brother as Dean struggles to come to grips with the residual feelings he has for Cassie.
With the IAD investigation in full force, Vic seeks legal representation from Becca Doyle for the Strike Team. Also, a suspicious Vic decides to confront Emolia after he begins to doubt her loyalty to him. Meanwhile, Dutch and Claudette investigate the ghastly murder of a pregnant woman. Tina continues to make mistakes while on duty.
On the day that Kev should be happily celebrating his 35th birthday, his mother throws herself from her balcony. To add to his woes, he sees his ex-wife Roxy, who's recently out of prison and far from reformed, at the funeral. Fatherhood has had a positive effect on Lip and Mandy.
Matt steps in to train Kris for a race while Pablo is out of town attending to personal matters, but all hell breaks lose on Raintree when Matt is suspected of breaking loyalties to help Dani train for the same race. With Charlie's help, Todd shows Jean that he can stand up for himself. Junior gets some unexpected help repairing damage to his club. Meanwhile, Isabelle shows her true motives.
As Sandy prepares to give birth, almost everyone rallies around her at the hospital. Everybody hopes that Martin--who has an important baseball tryout with a talent scout--will take what might be his very last chance to accept responsibility for his actions. Meanwhile, Kevin and Lucy are at odds over the idea of having more children, while Simon and Rose's relationship appears to be on its last straw--much to the Camden family's delight.
Jack contacts Mike and asks for a secret meeting in hopes of gathering evidence against Walt. Martha begs Aaron for help, while a desperate Walt tries to force Logan to aid him in his complicity with the terrorists. Buchanan butts heads with Lynn over a decision to violate the president's orders, while the Russians attempt to escape with the nerve gas.
Michael and his Wraith faction arrive at Atlantis to propose an alliance, hoping to use the retrovirus to transform their Wraith enemies into prey.
Marco's and Spinner's differing opinions over a controversial school issue threatens their friendship. Meanwhile Caitlin returns to help a troubled Spike.
Gene believes that local gangster Stephen Warren and the police can co-exist and that the streets are safer as a result. But Sam knows that in the future, dodgy deals like this will irrevocably change the relationship between the public and the police. Whilst Gene lays a ghost to rest, Sam sets to work on convincing his new partner, but is distracted when he meets his mother as a young woman.
New players and new blood leads to big pots. Sammy Farha, Eli Elezra, Shawn Sheikhan, and Todd Brunson join Daniel Negreanu, Doyle Brunson, Jennifer Harman, and Barry Greenstein for another High Stakes Poker cash game.
When evidence shows that a series of murders is linked to organized crime, Horatio and the team are instead lead to a pair of film students who have screenplay that contains the details of the crimes.
A friend of Lacey's visits Dog River and shocks the town with her behaviour. Lacey, using her past experience as a measuring stick, decides that this is just another case of Dog River not accepting outsiders; Hank devises a plan that will settle matters. At Corner Gas, Brent and Wanda try to stop the points card program from going out of control, while Davis considers just how good, or bad, Karen is at undercover work.
While Tina and Helena attend a documentary screening, Bette leaves for Washington D.C. to speak at a Senate hearing and meets with Senator Barbara Grisham. Attempting to provide for both herself and Moira, Jenny puts her dreams of becoming a writer on hold and starts waitressing at The Planet. Jenny and Moira are also invited to a party hosted by Billie Blaikie where Moira meets like-minded people. Meanwhile, Carmen has to decide whether to give up Shane's opening party in exchange for a once-in-a-lifetime opportunity to DJ at an exclusive VIP party, and Dana plays at a tennis tournament and declares her love for Lara in front of TV cameras.
After Bart steals a key from Principal Skinner's office and gets himself into hot water, Marge and Homer send him to a behavior modification camp.
A broke Francis gets talked into getting a real job by Dewey, but one of Francis' rocker friends decides to offer him the position of tour manager of his band instead. Back home, Hal takes over the college recruiters, which Malcolm refuses to meet with, and treats each one as a suitor. However, Hal's plans are ruined when Malcolm chooses to go Harvard.
All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr. Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR.