Beverly Barlow returns to town just as a parasitic bacterium threatens to destroy Eureka, by turning everything to gold and then into rust --- people included.
Things are shaken up when the male beauty and the female geek finally move into the mansion. Meanwhile, the geeks are challenged to write an autobiographical rap to be performed for Three 6 Mafia, and the beauties must study politics and later put their newfound knowledge to the test while debating each other.
The NCIS team uncover a huge secret, as their mission to capture La Grenouille comes to an explosive and deadly conclusion.
After a skull smashes into the windshield of a teenager's car, the investigation reveals the skull has been gnawed on by human teeth, which implies cannibalism and marks the beginning of the Widow's Son case. Meanwhile, Angela and Hodgins hire a private investigator to find her husband. Bones searches for Zach's replacement and the team gets a wonderful surprise.
Benson and Stabler investigate a suspected child abuse case only to learn that the woman who reported it is the real case.
Sixty-five million years ago, a comet hit the earth, putting an end to life as it then was. Now a comet is about to hit the earth again. In the dramatised part of this episode, Fernando Martinez, a Mexican who works in Houston, Texas, sets off home to be with his family, the Vaton family in France seeks shelter, and the Baka pygmy tribesmen continue to hunt, unaware of the impending disaster. Astrophysicist Noah Boyle, and computer scientist Shiang Yatan, remain at the observation centre in Hawaii to try to find out exactly when the comet will hit.
When career criminal Wolfgang West gets put away for four years, his wife Cheryl decides it's time for her family to go straight. But can the Wests change the habits of a lifetime?
With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.
Princess Pea was practicing princess twirls for her recital but she keeps falling down. The Super Readers visit the Ugly Duckling book. They discuss the book and Princess Pea learns that practice makes perfect.
Jonas is still in hiding, Mack and Hector are still imprisoned, Charles is on the run, Bob is in Mexico, working for the CIA and Colonel Ryan is again called to answer question before a Congressional hearing.
Senior partner Carl Sack clashes with Denny after the latter is arrested. Meanwhile, Shirley needs Alan's help when a university wants a donation, and Jerry assists another new attorney in a homicide case.
Derek's mom tries to get him to live with her in Spain for six months.
Sam Oliver has always been the slacker with no goals or purpose. However, his life takes an unprecedented new direction on his twenty-first birthday, when he discovers that his parents sold his soul to the devil and he must now become Satan's personal bounty hunter.
Patty Hewes and Arthur Frobisher continue to struggle for dominance as the deposition nears.
Oscar's complaints about the lack of Dog River-oriented cable programming bring results, and Brent is chosen to select one show created and filmed in town. Brent takes advantage of the bribes he's getting while thinking about the shows. Wanda, Lacey and Emma can't agree on what type of show they want, while Hank finds himself the unsuspecting suspect in Davis and Karen's police show.
Hank is disturbed by Becca's negative reaction towards the concept of happy endings, even more so when he finds out that it is partially his fault. Marcy comes up with the idea of a threesome with Charlie and Dani, but it ends unexpectedly.
Jeff's snoring has gotten out of hands. Audrey, who isn't able to sleep anymore, decides that she and Jeff should sleep in separate bedrooms. While this could seems like a bad situation for some, other like Jeff see the good side of it. Jeff takes advantage of his new found freedom by staying up too late and living like a college student.
Four months after the events of the showdown between Sylar and Peter, new Heroes emerge. These include brother and sister Alejandro and Maya. Hiro remains in the past, but what will come of this? Someone dies and someone isn't dead. Claire and her father and the rest of their family get a new life.