Al is excited when Bud decides to move out, but a bit disappointed when Bud moves back in to the basement, and even more horrified when Peg's mother comes to live with them after splitting up with Peg's father.
With Mr. Burns shot, Chief Wiggum investigates the crime, and nearly everyone in town has a motive. At the end, it all comes down to the Simpson DNA.
Bishop, Shard, and the alternate-present versions of Wolverine & Storm, will have one more chance to save Xavier from being killed before he founded the X-Men... if they can survive the alternate-future ruled entirely unopposed by Mastermold.
The six supervillains can't believe their eyes when Spider-Man walks into their trap at the warehouse. But it's obvious why, when they easily overcome and unmask the fraud. Meanwhile, Silvermane and the Crime Lords grow more disenchanted with The Kingpin and want to put him out of business. Kingpin beats them to the punch, kidnapping Silvermane. Can Spider-Man save the day?
In the course of giving Simon, the Monster hunter, a routine nightmare, Ickis gets sucked into Simon's brain. Ickis can see through Simon's eyes and discovers that he can control Simon's actions. Ickis takes Simon on a rampage through the city streets. Word spreads of this crazy man and he is finally detained by doctors. Oblina and Krumm must get Ickis out of Simon's brain before the cat scan reveals his existence.
Krumm, Ickis, and Oblina are sent on a scare mission in a museum. They come upon an old Egyptian mummy. Ickis thinks up a creative scare and places Krumm's eyes in the mummy's head. The museum curator thinks the mummy has come to life and puts it under heavy security. The scare was successful. The only problem is that Krumm's eyes are now stuck in the mummy. Our heroes must remove Krumm's eyes without getting caught. This episode features a romantic moment when Krumm is reunited with his eyes.
Matt and Andy mix like oil and water with Joe, who means to collect his share of their late father's garage.
Ms. Frizzle takes the class on a field trip to R.U. Humerus's Body Shop. They learn how bones, muscles and joints all work together to help us move.
Dr. Scratchansniff has only one player for his weekly bingo game – Wakko.
Slappy's plans to take Skippy to a baseball game at Dodger Stadium go wrong when an opera performance by the famed Domino, Pepperoni, and Carumba is scheduled for that night instead. The singers (a parody of the Three Tenors) return at the end of the show to perform a shortened version of the Animaniacs theme. This episode also features parodies of Close Encounters of the Third Kind and Simon.
Yakko and Dot explain to Wakko through song about how to read the headlines in Variety Magazine.
Lindsay is nominated for Homecoming Queen, and so is Maria, even though she really doesn't want it, but she soon becomes competitive. Mr. B asks Rachel to help tutor star football player Todd Green to keep him eligible. She finds that Todd can grasp things she tells him very well, but he has great difficulty reading. An attraction develops between Todd and Rachel. Meanwhile, the Homecoming Queen campaign has gotten heated with Ryan and Tommy working for Lindsay and R.J. becoming Maria's manager. The campaign gets dirty when Maria is accused of being a Valley High ""traitor."" Todd fails to complete the test he's been studying for. Rachel tells Mr. B. about Todd's problems. The principal suspects Todd might have a form of dyslexia. Todd is mad at Rachel at first but things get straightened out and Todd passes a verbal makeup test. Lindsay and Maria stop the dirty campaigning and vow that whoever wins will give the crown to the other girl. Who wins? Rachel, as a write-in!
Maria is getting a car for her 16th birthday, but she's failing Driver's Education. She pleads with Screech to pass her, and he agrees against his better judgment. Meanwhile Ryan needs a car to compete with Tommy for Lindsay. He gets the idea of pooling money to buy one and he recruits Rachel, R.J. and various nerds, jocks and band members to join in with him. When he's still $600 short, he gets a rich kid named Arthur to go in on the deal by using Rachel as bait. Rachel can't stand Arthur and gets mad at the boys for using her. Later, Maria is out driving with her friends when she hits Mr. Belding's parked car. Ryan and the gang use their money to buy an identical car while Mr. B's is being fixed. But the other partners show up and demand to have their turn in the new car. When Mr. Belding shows up and sees all the students piled into what he thinks is his car, he demands to know what's going on. Maria and Screech both own up to their mistakes.
Freakazoid rescues campers from a monster and narrowly escapes a lobotomy. Toby Danger must stop Dr. Sin.
Mozenrath hires the Muktar to capture Genie. Muktar hunts down every one of Genie's friends and leaves Genie for Mozenrath, but struck by Genie's friendship he decides to help Genie defeat Mozenrath and free the others.
The Tick is sent into space to blow the ""CHA"" out of the Moon from when Chairface tried to write his name in the moon. He blows the letter C up while he's inside it and gets sent through space. While in space he comes across a fantastically large alien named Omnipotus. The Tick befriends him and becomes a janitor on his body. But Omnipotus is an eater of planets and plans to eat the Earth when they get to it.
While watching video tapes of old battles, Raphael sees a mystery person spying on them. While the Turtles investigate, an alien warlord named Dregg sends his TechnoGansters to steal all the gold on Earth.