Sam and Dean are left to pick up the pieces after the loss of their mother, the demise of Crowley and the heartbreaking death of Castiel. The birth of Jack leaves the Winchester brothers with differing opinions on how to deal with a Nephilim. After being dragged into the breach, Mary must learn to survive Lucifer and an apocalyptic world.
Lt. Casey gets off on the wrong foot with Sam Mullins, a temporary Chief who is filling in for Boden at House 51 for the morning. When Casey later makes a risky move in an attempt to save a distraught man from jumping off a building, Mullins has a surprise that Casey does not expect. Mouch flies in Cruz's brother Leon as a birthday surprise, but the rest of the squad struggles to keep it a secret. Meanwhile, Brett is caught off guard when she learns new information about her hometown friend Hope.
Roguish smuggler Billy sails into Port Moore to find his hometown disturbed by recent events, and as he moves to distribute his latest shipment, his beloved boat and only escape is overtaken by a presence of his past.
With an unknown killer hunting them and the boundary continuing to shrink, tensions are running high as time looks to be running out for the Risen.
A two-year old mastiff with a bone tumour in its leg undergoes pioneering surgery, only to return a few weeks later suffering pain in its foot. A tiny pug faces the prospect of euthanasia after losing control of its hind legs, but neurologist Colin Driver thinks spinal surgery could give hope, and a Rhodesian ridgeback is brought in suffering from lameness. Surgery seems like the only option, but Noel and the owners are concerned whether this is the right course of action in the long run.
Amelia confronts a difficult situation, while Meredith deals with the fallout from her conversation with Nathan. Maggie finds herself at an awkward family dinner, Jackson receives big news, and Richard and Bailey search for the stars of tomorrow.
Tahani throws a dinner party to impress. Eleanor and Jason both have to lend a hand when things don't go as planned.
Bruce Wayne puts the lives of Gotham Natural History Museum historian Niles Winthrop and his grandson, Alex, in danger in an attempt to uncover the meaning behind his prized knife from the auction. Meanwhile, Ra's Al Ghul proves he'll take deadly measures to achieve what he wants. Also, with Sofia Falcone in town, she is on a mission to win back Gotham from Penguin.
Diana has been promoted again, this time to the head of the corporation that owns MMN, but before she leaves she finds herself embroiled in a sexual harassment scandal. This leaves Katie unsure who to believe - her mentor or her friends in the office. Carol becomes head intern and struggles to prove to the other interns, and herself, that she deserves the job.
Whitey visits the Worth home to exact revenge, but finds himself on the back foot. Elizabeth confronts Gagnon about his interest in bringing down Jim.
One castaway's romantic feelings for another tribemate may cause them to spill secrets, and another castaway's lack of social skills could prove to be a problem.
As Fred's life hangs in the balance following the shooting at Pop's diner, Archie struggles with the emotional aftermath of what he witnessed. Meanwhile, as Veronica steps out of her comfort zone to support Archie, she learns that her father Hiram has arrived to Riverdale earlier than expected. Elsewhere, at Pop's diner, Pop Tate recounts the chilling details of the shooting, which leaves Jughead and Betty questioning the gunman's true motives. Lastly, after running into Cheryl at the hospital, Betty and Kevin are surprised to learn about the fire at Thornhill.
While the Task Force investigates a series of suspicious police shootings, Agent Ressler is distracted by increasing external pressures. With his back up against the wall, Red drafts Tom in executing an elaborate plan to help re-establish his criminal reputation.
Phil’s convinced he is going to have a day of bad luck after failing to successfully complete his daily superstition. However, Claire is eager to make it to a concert and has no time for his silly notion. Meanwhile, Mitch is certain that Cam is undermining him during their kitchen renovation, and Jay is determined to get Gloria to admit she was in a car accident.
Beverly confronts Coach Mellor who reveals his strained relationship with his own brother Coach Nick, so she intervenes prompting Nick to face off with Rick. Adam and Barry join in, each one siding with one of the coaches. After a fight breaks out, Beverly points out to Adam and Barry this could be them as adults. Meanwhile, Geoff and Erica struggle with their relationship long distance.
Morwenna’s parents Jack and Tara pay a surprise visit, having been working as missionaries in Kenya. However, the reunion is tinged with sadness when it turns out that Morwenna’s mother has liver cancer, and has decided against treatment because of her faith. Louisa’s first online call for her new course does not go as planned – especially when Martin tells the lecturer exactly what he thinks – and Joe investigates a break-in at the school where nothing has been stolen. Martin Clunes stars in the comedy drama, with Jessica Ransom, Caroline Catz, John Marquez, Kevin Doyle and Rebecca Lacey.
When successful businessmen in Detroit are targeted by an anger-driven power-assertive Unsub, the BAU is called in to investigate.
Gretchen goes home for the birth of her brother’s baby, but instead ends up reconnecting with a friend from her past, who inadvertently reveals why Jimmy may have left her.