Heidi decides to throw Lauren a surprise 21st birthday party and tells her about Spencer asking her to move in with him. Jen tries to apologize to Lauren but instead makes excuses, thus, Lauren doesn't accept her apology.
The action picks up thanks to Antonio Esfandiari. Mike Matusow, Daniel Negreanu, and Phil Laak join "The Magician" for another episode of High Stakes Poker.
After a wealthy businessman is killed at a charity event the CSI's first suspect his wife who was hosting the event. The blood evidence is thought to belong to the wife or her two secret twin sisters but leads the investigators in another direction after the victim is not who they thought he was.
Lynn continues to work at the church with Eldon, despite the status of their affair. William decides to give the girls the silent treatment.
When Eddie's childhood friend Dana Taylor witness a murder she becomes the killer's next target. Dana seeks Eddie's help for protection and support which fuels Jen's anger.
Alan tries to bond with Jake when he realizes that his childhood is almost over. Kandi pursues a career in acting.
CTU's satellite tracking system is compromised as a bomb-carrying drone heads toward an unknown city. Meanwhile, US forces prepare for a nuclear retaliation on the Middle East.
Chris is a hit as a DJ after the neighborhood DJ gets arrested during a party. Chris has a problem when he scratches Rochelle's James Brown album. Julius passes out when he sees a rabbit at a magic show he takes Drew to.
Sara sacrifices herself for the safety of Michael so the brothers can get on with their final plan to attain freedom, but their plan gets 'shipwrecked'. Meanwhile, Bellick blackmails Sucre to partner up as T-Bag's streak of murder continues to the south of the border.
Barney takes drastic measures to prevent Ted from moving into Robin's apartment. Meanwhile, Marshall and Lily are discovering the ups and downs of having the apartment to themselves. Barney considers moving in with Marshall and Lily.
Hoping to collect the Donnellys' debt, Nicky threatens their mom, Helen. Sean comes home; Jimmy and Joey collect Louie Downtown's payments; Tommy takes a bribe.
Christine vows to become more aware of politics when Richard scolds her about her indifference towards an upcoming election setting a bad example for Ritchie.
The rivalry between Matt and Junior heats up; Gillian returns to town and finds solace with Junior.
Five teenagers must locate and secure ancient relics with unbelievable power, while at the same time stop a demonic corporation who want the relics for their power.
The 1999 murder of a homeless woman, whose body is found at the bottom of a river in a station wagon, is investigated.
Chase's birthday is coming up but he's too busy writing a 5000 word paper to even care. When Zoey hears Chase and his grandmother share the same birthday she thinks she has the perfect gift for him, to bring his grandmother to PCA. Logan and Michael argue about the theme of Chase's party. However, the plan falls apart when Chase hears that his grandmother dies. Zoey hears it from Michael and she goes to comfort Chase even in the heavy rainstorm happening during the scene.
Baltar's trial testimony threatens the very stability of the fleet. Lee assists Romo Lampkin in Baltar's defense. Some in the fleet begin to feel that Baltar is divine. Though he dismisses such beliefs, Number Six suggests that the followers may know more about his true nature than Baltar does himself.
Dilly is surprised when he finds a batch of cooked shrimp washed ashore and Krunk trips on his way to investigate.
Bette finds out that Jodi's been offered a job at an art center on the East Coast. Tasha's memories of the war continue to haunt her, and she is ordered to keep her sexual orientation a secret. Meanwhile, Shane plans a surprise for Paige, Helena is kicked out of the hotel, and Max comes to a decision regarding his job.