Bart goes from hero to goat on his Little League team after an error in the championship game. Meanwhile, Homer falls asleep on a bed in a department store. When he's awakened, he raves about the mattress and is given a job as a salesman.
Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.
Vicki and Henry have a run in with Medusa, the gorgon of Greek lore. While looking for a missing male model.
Maria Spatafore requests help from Tony for Vito, Jr. Tony's bad luck puts a rift between he and Hesh. A.J. makes a major choice regarding his future.
Lois gets a job as the church organist, so the family decides to begin going back to church. When Stewie gets sick after receiving communion, the congregation becomes convinced that he has been possessed by the devil. While on the run, the family ends up in Texas, where Peter begins to fit right in with the cowboys, Stewie enters the "Little Miss Texas" pageant, and Chris and Meg sneak into George W. Bush's house.
Henry is shocked when he learns that his ally, Emperor Charles V of Spain, has released France's King Francis I from prison. He's equally surprised when Anne Boleyn turns him down after offering to make her his sole mistress.
Kimball tries arresting a magician performing without a permit, who cano get out of whatever restraint she places on him. Dangle accidentally releases a child killer free. A customer wants to file a complaint against the brothel for fraud. Junior and Jones deal with a drunk at a Renaissance Festival.
Mayko tries to get rid of the pain she's feeling in her phantom limb; the team investigates the high level of mercury contamination found in Lake McGraw.
After Stan discovers that Francine has a secret sex garden, he feels like their marriage may be crumbling. Looking to rekindle their romance, Francine asks for a divorce so that Stan can experience life as a bachelor again, and both learn a valuable lesson in love. Meanwhile, addicted to an energy drink, Steve finds himself panhandling in the streets to support his new habit.
On 2 June 1983, a fire breaks out on Air Canada Flight 797 in the aircraft's toilet. An emergency landing is made in Cincinnati, but the aircraft is engulfed by flames on the runway, killing 23 people, including musician Stan Rogers. The opening of the aircraft's doors after the landing caused a flashover.
Orel is chosen by Principal Fakey to represent Diorama Elementary in the Praying Bee competition. Stressing out and unable to pray, Orel finds himself turning to the Buddhist method of meditation.
The team searches for Chris Manning, a family court judge with a soft side who went missing after meeting with a young boy caught between his mother and his abusive father. Suspicion initially turns anyone Manning may have riled up due to his court rulings, but after his clerk is shot in what appears to be an attempt on Manning's life, the team learns that the secret behind Manning's disappearance is tied up with something that happened over twenty years earlier.
Bubbles and the boys get to meet heavy metal singer Sebastian Bach when they travel to Maine to attend a model train convention.
With plans for another child, Lucy tells Kevin that it might not be a good idea to move so far away from the rest of the family. T-Bone confides to Eric that he's having second thoughts about breaking up with Ruthie, who is spending all of her free time lately with her former crush, Martin. Sandy's boyfriend surprises her with a marriage proposal, and T-Bone's estranged father shows up on the Camdens' doorstep.
The 1998 death of a terminally ill man who died months before he was expected to is investigated after a nurse confesses to six so-called mercy killings.
Rebecca tells Justin that Joe kissed her. Joe tries to confess to Sarah about the kiss, but before he can get enough courage, she receives the news from the most unexpected person. When Nora fails her writing class, her teacher allows her to pass on one condition - she must go on a date with him. And, Kitty has to calm the Senator down after a disastrous helicopter crash.
A woman arrives at the offices claiming her ex-employer has stolen her baby. Beatrice causes mayhem by shredding documents and sticking labels to everything. Peter has the call to Simon's phone traced, learning that it came from an anonymous international number. He has a heart-to-heart with Auriel as the locals prepare for the 127th annual Dyke Leaping Championships. Peter discovers Simon's driving licence is in the name of "Christopher Waller", a deceased client.
After Bill survives a roof cave-in over his bed he has a religious experience which involves a romantic liaison with Reverend Stroup.