George steps in to be Jason's sports agent when NFL Quarterbacks Daunte Culpepper and Donovan McNabb (guest starring as themselves) pay a visit to the Lopez household to draft Jason for their alma maters and a minor league baseball recruiter approaches him for a contract. Meanwhile, Carmen and Los Lobos guitarist Cesar Rosas stir things up at George's family birthday bash.
Michael buys an R.V. and the family heads to the Grand Canyon for a vacation.
Gigi is pulled out of her depression when a call from her agent brings news of a job – a gig for a cable network movie shooting in the Rockies. Not realizing she is merely the movie’s required Canadian content, Gigi ventures north in search of a break from Los Angeles and her ex-boyfriend Payne. Her wish comes true when she meets (and beds) Bo, the Olympic bobsledder – only to find out later he’s an anti-Semite.
In the hopes of getting closer to Phyllis, Dee Dee sets her up with her bitter divorced professor. However, the relationship soon fizzles, and the professor seeks revenge against Phyllis by turning her in for having too many cats. Phyllis blames Dee Dee, whose efforts to correct the situation only wind up making it worse.
In 1996 a beautiful newlywed, was attacked and left for dead. The only thing taken was her wedding ring and she has been in a coma ever since. The man jailed for the crime is now a born-again Christian and is protesting his innocence
Ephram prepares to leave for Europe as he feels that he has nothing left for him in Everwood. However, he's caught off-guard and questions his plans when Andy reveals the secret that Amy has been keeping from Ephram. Meanwhile, Nina and Jake contemplate going into business together, but the stress on their relationship proves a big obstacle to overcome. Meanwhile, Bright finally confesses he has feelings for Hannah.
Jack finds that his efforts to bargain with Marwan for the location of the missile strike are futile. Heller pushes his son for information when CTU discovers that he may have had contact with Marwan before the attacks. Logan finds himself in the middle of a power struggle between Palmer and the ambitious Speaker of the House. Tony and Michelle explore their rekindled passion for each other, but their hopes for the future may be short-lived when a familiar player enters the game and takes a hostage.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
An axe murderer on death row is given a stay of execution just moments before it was to take place, on the grounds that there may have been tainted DNA analysis used at his trial. Now, without using any DNA evidence, the team must race against time and reexamine all of the physical evidence in the case, just as they get a call on a new double murder that looks suspiciously like the case they're working on.
With graduation quickly approaching, Flex's ex-wife Nicole (Tichina Arnold) convinces him to meddle in Breanna's love life, hoping she will choose a college in California over staying in Baltimore with Arnaz. Later, Arnaz tells Breanna that she should go to California to follow her dreams, but she thinks it's his way of breaking up with her.
After Darnell reveals that he has failed to get a band for his wedding (which is just two days away), Maya recommends that he hire Lynn's band. However, Lena is not impressed after hearing the group perform, and lashes out at Darnell. He turns around and blames Maya for the fight, accusing her of trying to sabotage the wedding. Darnell shows up at Maya's apartment drunk after the bachelor party and says that he loves her. Meanwhile, Lynn continues to battle her feelings of jealousy regarding Finn. William begins to complain about the restaurant, prompting Joan to suggest that he is actually dealing with issues about their break-up. After going into false labor, Toni vows to live life to its fullest in the short time left before she gives birth.
Ray fears getting his adenoids removed, but Debra convinces him to go through with the surgery. At the hospital, while Marie is in the bathroom, and everyone else in the waiting room, the nurse comes out and tells Debra that Ray isn't waking up from the anaesthesia.
When a person who was killed right in front of Phoebe comes back from the dead to blame her, she becomes guilt-ridden and vulnerable, creating an opportunity for Zankou to steal the Book of Shadows. Meanwhile, Paige has a new charge who knows nothing about magic, and Piper and Leo attempt to plan Chris's first birthday party.
Flanders rents a room to two college girls who, without his knowledge, use the spare room to broadcast live softcore pornographic web videos of themselves. Upset that no one in town told him this (and that Homer was the one who told everyone), Ned moves to the seemingly perfect town of Humbleton, Pennsylvania, while a brash coach moves into Flanders' house and begins harassing Homer the same way Homer harassed Ned.
Bart gets expelled from school and transfers to a Catholic school, where a hip priest named Father Sean tries to convert Bart and Homer to Catholicism, which worries Marge when she believes that Catholics do not go to the same heaven as Protestants and discovers that Catholic women do not use birth control.
Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.
Unbeknownst to Lois, the boys enter her in the Mrs. Tri-County Pageant as a joke. When they overhear the other contestants remarking that Lois doesn't have a chance of winning, they plot to help their mother take the crown. Meanwhile, Malcolm is blackmailed into delivering love notes to a contestant for Herkabe, and Reese discovers that, according to the Mrs. Tri-County Pageant manual's scientific formula, he is beautiful.
Evelyn demands Jake spend a night at her place when she finds out he spent Spring Break with Judith's parents. Neither Alan nor Charlie are keen on the idea, but going to a bar after dropping off Jake quickly erases their concerns.
After Mort bowls a perfect game, and Quagmire gets a key to the city by performing CPR, Peter notices he has nothing to be proud of. He then attempts to achieve fame by setting the world's record for most nickels swallowed. However, a slight miscalculation leaves him blind with nickel poisoning.