Meredith grows increasingly dissatisfied with the unknown details of Derek's life. Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recovery; Izzie contemplates reconnecting with her estranged mother; Zoey, a pregnant woman in her 40s who's been diagnosed with cancer, disagrees with Cristina's medical advice; and the interns are mystified by Cable, a patient who's being treated for seizures and who thinks he's psychic.
Some new evidence comes to light in an old case that involves Dr. Macy. Jordan is placed in charge of the case that will either make or break Dr. Macy. Meanwhile, Woody is hot on the trail of a cop killer, and Woody finds himself looking down the barrel of a gun.
Bill finds happiness in a men's chorus, where the required devotion jeopardizes his Army career.
When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin.
Sue and the team investigate a bank robbery but this bank robbery becomes a little more interesting than the team expected. They find out that the bank they are investigating was robbed several years earlier. This time they learn that three girls have robbed the bank, which begins to seem strange to the team. When they robbed the bank they stole shoulder pads and one of the girls is the daughter of the president of the bank that was being robbed. Lucy has a mystery of for a long to figure out after her grandmother gives her a jewelry box. When the team opens the box to find out what it contains they are all very surprised at what falls out of the box. Lucy learns that the letters her grandmother kept were from her first love named Oscar. Sue and Lucy decide to track down Oscar because he still wants to see Lucy's grandmother. Lucy is shocked when her grandmother learns of her surprise.
Jonsey's new gig as the production assistant for local cable access isn't moving his new ""film career"" forward as quickly as possible, so he decides to film his own, ""Prank T.V."". And the first victim - Nikki. Caitlin agrees to be an accomplice and convinces her to spend the day with her getting a girlie make-over. Nikki reluctantly agrees and endures her personal nightmare of a day - manicures, waxing, and the ultimate horror - bikini shopping - all to make Caitlin feel better about getting dumped by a guy she wasn't even dating. But what will Nikki do to them when she finds out she's been pranked?
Bubbles pretends to be a spaceman when the boys buy a rocket set. Ray reveals Lahey's secret and Lahey goes off the deep end.
A surprise guest shows up at a sad event as Bette gets stunning news about her job. Tina goes into a surprisingly difficult labor, Jenny finally reaches breaking point over her painful childhood memory, Alice struggles with her jealousy, and Peggy Peabody lays down the laws with her daughter, Helena.
When the body of a man is found and it soon becomes obvious the body has been moved, Eames and Goren investigate the death of Walter Czabo, whose wife has been sleeping with a decorated former police officer who happens to have close ties to Deakins. The suspects start piling up, starting with Frank Adair and leading to his controlling publicist, but Deakins is reluctant to go after his friend, who wields a lot of local influence, without good, hard proof.
Rose requests a trip back to the day her father, Pete Tyler, died. Reluctantly, the Doctor agrees, but he realises he has made a mistake, when Rose saves Pete from being run over by a car. This has now changed the timeline, and Reapers are transposing themselves all over the Universe. However, this time, the Doctor doesn't have a plan…
During a museum robbery, a partnership is formed between Catwoman and Penguin. But when Penguin double-crosses Catwoman before she can double-cross him, she and Batman have to stop Penguin before he unleashes his true plan: harnessing the power of Ra!
Jermaine returns and joins the Warriors as a Wudai Warrior, which is more advanced than a Xiaolin Apprentice. Omi is discouraged that Jermaine is ranked higher than him, and they constantly confront each other because of it. Jack soon learns that Jermaine's master is Chase Young, who doesn't know Chase is on the side of evil. Upon hearing this, the Warriors rush to notify Jermaine before it's too late. However, because of his encounter with Omi earlier, Jermaine refuses to listen.
After Jack inadvertantly releases the world's most biggest and powerful spiders, the Warriors, Jack, and Chase Young temporarily team up to stop the spiders before they proceed to consume the world. Kimiko, Raimundo, Clay, and Jack are captured while Chase and Omi escape. To look for an answer on how to defeat the spiders, they combine the Fountain of Hui and Eagle Scope. Will Omi and Chase be able to find the answer and put an end to the spiders' reign?
After the terrible injuries sustained in the last race, Hot Shot cannot finish the final race on his own... Leaving Koby to enter the tournament as Hot Shot's driver.
Six years in the future, an emotional Captain Archer and the crew return to Earth to face the decommission of Enterprise and signing of the Federation charter.
A human isolationist leader threatens to destroy Starfleet Command unless all aliens leave Earth immediately.
A dangerous felon escapes when a prison bus crashes and the FBI has reason to fear he's intent on revenge against the witness whose testimony put him in jail. However, finding the elusive killer proves to be a complicated challenge. Don teams up with Agent Billy Cooper, his former partner from the FBI's Fugitive Recovery Division, and Alan worries that Don's going to return to a more dark and obsessive time in his career.
Plankton tries to steal the formula, but slips and sues Mr. Krabs. Mr. Krabs hires a lawyer, but his lawyer slips and is hurt, so SpongeBob must try to help Mr. Krabs win the case by trying to open a briefcase that has something very important in it.
Mr. Krabs complains that his back hurts, so SpongeBob and Patrick buy a new mattress and Squidward tries to take credit for it. They give the new mattress to Mr. Krabs, but Mr. Krabs put his money in his old mattress, which SpongeBob, Patrick, and Squidward must find while Mr. Krabs is at the hospital.