Randy makes an odd request of Sue. He asks her for some help with woman he is about to meet there is one problem in the correspondence Randy and his date have shared over the computer she forgot to tell Randy she was deaf. Sue now has to accompany Randy on his date to help him with the sign language.
Leonardo and Usagi arrive in the Battle Nexus hoping for a way to reunite the four turtles and their master. But they find the Battle Nexus under the control of the evil Ultimate Drako and Master Splinter is his prisoner.
After the "Atlantis" ship disappeared, Optimus Prime and Megatron head to the moon where it's hiding while Vector Prime and the kids locate the Omega Lock. Will the Autobots prevent the Decepticons from getting the Omega Lock? And what does a side-changing Transformer named Sideways have planned?
The Doctor takes Rose on her first voyage through time: to the year five billion, when the Sun is about to expand and swallow the Earth. She is cautious and soon starts to question her reasons for joining The Doctor. But amongst the powerful alien races gathering to watch on Platform One, a murderer is at work. Who is controlling the mysterious and deadly metal spiders?
The Mystery Kids head for a NASCAR-like championship race where mayhem is taking place on the racetracks.
When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.
A man wanted for stock fraud is found garroted in his apartment, and the crime is eerily similar to a murder committed a year earlier, a case in which Don closed when an ex-con confessed. Now, Don must re-investigate the old case to determine if he put an innocent man in jail. He asks Charlie to go over the evidence to see if he missed anything the first time around.
Officially a full-time teacher, C.J. is overjoyed to finally get access to the teachers' lounge. But he soon finds himself being bullied out of the room by the school's overzealous Home Ec instructor. Rory wants to impress a girl, so Bridget and Kerry take it upon themselves to give him a full-fledged makeover.
When Billy and Mandy's school is preparing for a big game, Mindy entrusts the care of the school's mascot, Fluffy Cat, to Billy, to protect him from being kidnapped by the rival team, the Booty Heads. At Billy's house, Fluffy Cat is a disaster, so Billy's mom throws him into the basement, where the cat gets inside Grim's trunk, absorbing its powers. A giant Fluffy Cat appears just before the game wreaking havoc.
As Billy is tired of all the rules in his house, he cannot resist the urge to try his father's new motorcycle. The motorcycle breaks down, and Billy asks Grim to repair it. Grim's scythe turns the motorcycle into a wild, supernatural vehicle, which transforms Billy's parents and everyone around it into undead creatures and motorized monsters. Mandy makes Billy tell the truth about breaking the motorcycle in the first place, at which point his parents and everyone else return to normal.
Zack and Cody have two pet rats as a science project. Mr. Moseby gives the twins tickets to a Red Sox's game to get them away from the hotel. Then a hotel inspector seizes control of the Tipton, because of Zack's mistake. London has a dog party for Ivana and Maddie has to plan.
When Kim discovers that Ron has missed practice and their daily trip to Bueno Nacho, she finds out that television is the reason he has been busy. She manages to get him and they head out to stop Dr. Drakken and Shego to get back the Pan-Dimensional Vortex Inducer, but when his laser goes awry and sucks them into a television world, Ron’s newfound knowledge of television may just prove useful.
Kibre tries a celebrity basketball star accused of raping and murdering his mistress. However, she runs into trouble when the star's wife has a slip of the tongue on the stand.
Bernie wants to encourage Vanessa's burgeoning musical talent. Guest appearance by Isaac Hayes.
Experiment 133: PJ Lilo's always getting blamed for Mertle's pranks, so she figures it's high-time to pull a few pranks of her own, and what better prank-ee than the mean old substitute hula teacher?
When Stephanie Healy doesn't show up for choir practice, the team heads in to investigate and soon learns Stephanie had recently had a fight with her boyfriend. While speaking with Eddie, the team is shocked to learn that Stephanie used to be Stephen Patrick Healy. Convinced that the truth to what is happening in Stephanie's present lies in her past, the team investigates who Stephen was. Vivian has trouble hiding her worsening problems from the team, and is upset that Martin has been talking to Sam about his suspicions.
When a psychiatrist is gunned down, Tru tries to identify the killer… but Jacks meddling implicates her in the murder.
Jack comes back to town two months after the events of the Season One finale. Tru's dad decides to move to town. Harrison has been at a new job for six weeks. Tru has started med school, thanks to Davis pulling some strings. When a young Harbor Patrol officer dies in a white squall while rescuing some students and asks for help, Tru has to compete against Jack to save her life.