When an old flame of Angie's moves back to town to become a news anchor, George becomes jealous with her giddy excitement over him. But George comes to find out that Angie has not told him the whole story about this former boyfriend.
When Jay tells Michael that their love life will be even better if they are celibate for six months, Michael is willing to abide by her wishes, although reluctantly. Meanwhile, Franklin and Kady plant some seeds in the ground to symbolize their growing love for each other, but the seeds grow into an ingredient for a love potion that Jay uses to spice up her romantic dinner for Michael.
When Denise Eldridge finds her fifteen-year-old daughter Carrie in bed with twenty-one-year-old Justin, she immediately calls police to have Justin charged with statuatory rape. Benson intercedes on behalf of Carrie, calling a children's rights lawyer to assist her, but when Denise turns up dead, Carrie and Justin both end up on the suspect list. Benson tries to get some help from Simone Bryce, but Bryce is obligated to protect her client.
Flex tries his best to make things work with Tonya (guest star Tamala Jones), but that becomes more difficult when he learns Danielle's true feelings for him. Meanwhile, Breanna's obsession with being crowned ""cutest couple"" with Arnaz for her school yearbook causes a rift between them
Following a fight with his father, Lynn's brother Matthew shows up and asks to stay with her while he pursues his music career. She tries to help him when he freezes during an audition, but winds up being offered the job as lead singer instead of him. Meanwhile, Toni is extremely reluctant to give up her massive closet to make room for the baby; and William is confused by a thank-you gift from Maya.
Marwan decides to trade Jack for Behrooz in hopes of distracting CTU from his real objective. Tony and Michelle weigh the consequences of the trade, while Curtis reluctantly interrogates Behrooz in order to learn more about Marwan.
Forrest is still up in the air about his future in the contest, but he does get his stitches out and the healing is progressing nicely. The fighters continue their battle for the remaining spot in the middleweight finals.
The girlfriend of a convicted drug lord is killed on the night of his execution. The drug lord's ghost is seen at the crime scene, and Allison is brought in to investigate. Also, Allison discovers a dark secret about the mother of a boy that Ariel has a crush on.
When cutting-edge surveillance technology fails to catch a thief in the act, Ed must rely on good ol' human ingenuity to crack the case. Elsewhere, Mary (Nikki Cox) and Mike (James Lesure) intervene when a cheating husband is caught red-handed. Meanwhile, when Montecito's grooviest high-roller is in need of vintage duds, only Emmy-winner Don Knotts (as himself, "The Andy Griffith Show") can keep his polyester groove alive.
Lacey has just about had it when she finds out about yet another local function that no one invited her to - the Harvest Dance. Is it time for her to stop trying to fit in to Dog River? Meanwhile, Hank falls for a highway worker named Heather. But theirs becomes a forbidden love when the people of Dog River discover something about Heather they just can't accept. Finally Brent and Oscar scramble for reasons not to eat Emma's dreaded jelly salad.
Mona tries to comfort Dee Dee after Carter appears on a talk show and says that he is seeing someone. When she later discovers that Dee Dee and Carter have secretly reunited, an angry Mona declares that she will not help Dee Dee pick up the pieces after the new ""casual"" relationship fails. Meanwhile, Spencer tries to get into photography in the hopes of getting rich; and Dee Dee and Big Dee Dee face a crisis involving their hair stylist.
When a mass grave for the mob is found, the killer assaults Bug. Not long after the discovery Woody’s brother shows up sparking some suspicion. Lily and Nigel stay at Bug’s side waiting for him to wake up.
A woman, who was romantically involved with Nick Vera in high school, claims that members of a fraternity might have been involved in her alcoholic sister's death in 1995. The victim's estranged husband and a bar owner are also viewed as potential suspects.
Peggy follows Luanne onto a roller-derby team, where the tight-fisted owner prompts her to lead a revolt and form a team on borrowed money.
Gob and Buster team up for some magic tricks with the help of Buster's fake hand, but when Tony Wonder, a rival magician, starts to mentor them, somebody gets the finger. Meanwhile, Michael is forced to delegate some work when he's hospitalized and Lindsay teaches George Michael how to drive using the staircar.
Maisy Gibbons' series of unfortunate events shock the residents of Wisteria Lane when she is finally caught and arrested for prostitution. This leaves unexpected consequences for Bree and Rex when Maisys' little black book becomes public of all her clients. Gabrielle and Carlos also face a crisis of their own when the sewer system goes out at their house. Also, Lynette braves a scandal herself when it's rumored that the twins started the school's head lice epidemic. Meanwhile, as Susan sinks into depression over her breakup with Mike, she finds a surprising ally.
After Hal forbids Dewey from inviting his peculiar classmate Chad over for a sleepover, Dewey quickly finds out that his father had good reason to warm him. Meanwhile, Malcolm and Reese find out that they are not as popular as they once thought, then plot "revenge" on their classmates.
Alma fires Miss Isringhausen as her ward's tutor. Bullock struggles with domestic life. Cochran suggests a risky surgical procedure for an ailing Swearengen. Dority deals with a former associate's robbery proposal.
Meet Meredith Grey. Daughter of famous surgeon Ellis Grey and currently recovering from a one-night stand. She shoos away her evening's companion, saying she'll be late for her first day of work. She is a first year intern at Seattle Grace Hospital and is working alongside some colorful characters. Cristina Yang is a highly competitive Stanford graduate who befriends Meredith. George O'Malley is a quirky warm hearted man who learns a lesson or two on his first day. Izzie Stevens is a former model who doesn't get any special treatment on her first day. And Alex Karev is an arrogant jerk who misdiagnoses a patient on his first shift. Overseeing them is Miranda Bailey, (not-so-) affectionately dubbed 'The Nazi'. Meredith also gets a surprise when she realizes that her friend from the night before is a co-worker, and even worse, her boss.