With a brief opportunity to send a data transmission to Earth, members of the Atlantis expedition compose video messages home to their loved ones.
Edie organizes a neighborhood search for the missing Mrs. Huber, just as the absent busybody's sister Felicia Tilman arrives on Wisteria Lane. Meanwhile, Bree resigns herself to her marital state and asks an attractive pharmacist on a date. Susan's ex Karl suddenly reappears in her life, and Lynette fears that Tom is attracted to the new nanny. Lastly, Gabrielle sinks to new depths.. she gets a job.
Jack pushes Driscoll to reinstate him in the wake of Heller's kidnapping. He finds himself working as a subordinate when the Field Ops team goes to pick up Andrew. Behrooz finds himself torn between his loyalty to his parents and his feelings for his girlfriend as he is sent on his first assignment. Heller tries to comfort his daughter as his captors broadcast their intentions on the Internet.
Eighteen months have elapsed since the conclusion of Day 3. A commuter train bound for Los Angeles explodes. A man steals a suitcase from a passenger in the wreckage and then kills him. Jack has been dismissed from CTU and now works for Secretary of Defense James Heller. Jack is involved with Heller's daughter, Audrey, and their relationship is growing serious. Jack is in LA for a meeting with CTU Director Erin Driscoll, who fired him a year ago, but he finds himself alienated at CTU by Driscoll and the new staff when reports of a possible terrorist strike come in. A young computer hacker named Andrew Paige sees something that he shouldn't on the Internet. Suddenly, he finds himself running for his life as he is pursued by terrorists. Luckily, he is able to warn Chloe O'Brian before its too late. The Turkish Araz family are not what they seem and it becomes clear that they are heavily involved with the day's events. Meanwhile, Heller has a confrontation with his estranged son. Jack finds that Chloe is his only ally as he tries to prove that the train explosion is merely a diversionary target.
Huff grapples with the dangers of psychiatry when a young, eager and attractive pharmaceutical rep does her best to persuade him to aggressively prescribe. But Beth discovers an item in Izzy's closet that may be alarming enough to distract him from his flirtation. Over in the land of Russell, Huff's lawyer friend may be the victim of federal surveillance or simply the victim of his own paranoia.
A Sudanese native wants to sue the U.S. government for the lack of action taken against the mayhem happening in his country and Paul looks to Lori to take the case. Founding partner Shirley Schmidt arrives with a mission to bring order to the firm. While making herself known, she has to deal with Denny who does not wanting her there, help with Lori's extremely high profile case, and learns that she has to keep her eye on Alan. Alan ends up defending a man who killed his mother in a fit of rage but by accident.
When a rare orchid is smuggled illegally into Midsomer Malham it releases the heady scents of passion, jealousy and death.
Goren matches wits with a one-time chess prodigy who has become a fugitive when the body of a young woman is found tossed in the trash.
Notes: Bitsy has Ned pass a note and Sweeney catches him, now he must pay. He has to write an essay along with everyone else so they plot revenge. Cookie finds joy in forging notes, but danger comes when he leads the teachers to the forgers "domain". Best Friends: Moze continues her search for a new best friend with a quiz and whoever matches up closely is meant for her. But Moze ends up joining the Huge Crew. The Killer Bees recruit Cookie which puts Ned and Cookie's friendship to the test. Ned tries to find a new best friend in place of Cookie.
NorBAC has been taken over by a joint command to deal with a catastrophic smallpox scenario. Bob tries to find a cure for his dog that is suffering from histiocytosis. Jill comes clean with David about taking medication for her panic attacks. David discovers that the earlier "Miranda Virus" outbreak might be linked to the U.S. government's secret bio-chemical lab and that whoever manufactured the "Miranda Virus" may possess another, even more lethal, biological weapon.
Chris is questioned by police about the recruitment-center bombing, and has a special date with Meg.
When a lone gunman decides to commit murder inside the morgue, Jordan wonders if there is a connection to any of the recent admits. Where this case leads will cause Woody to dive deep into a world he does not know…to find the truth.
The team re-opens the case of Matthew Adams, a teen-aged cult member who apparently committed suicide back in 1978, when his sister comes forth with new evidence about the deprogrammer her family hired to rescue her brother.
Zoey's roommates, Nicole and Dana, constantly fight. So then, she decides to move in with the girl named, Quinn. After Zoey moves in, she thinks that it wasn't a good idea that she moved. So then, she wants to move back in with Nicole and Dana. But when she sees that Nicole and Dana are enjoying themselves after Zoey moves, she decides just to stay with Quinn, since she doesn't want to hurt her feelings. Meanwhile, Logan is pressuring Chase into keeping Zoey away from her roommates so Chase can spend more time with her.
Zoey begins life at PCA. She is nervous about the situation at first, but gets more comfortable when she meets her new friends; Dana, Quinn, Chase,Nicole, Logan, Michael. The girls and boys try to adjust to girls being allowed to attend PCA for the first time.
Star Contest comes to the mall, and when Wyatt performs his original song about how awesome his friends are, he wins the regional finals. He gets his big break opening for Utility Pole, but the gang all miss the concert due to unforeseen circumstances (boys, sales, exploiting Wyatt's new fame...). Upset that they all ditched his show, Wyatt rewrites the words to his song at the last minute to reflect his feelings and tells everyone his friends suck. Suddenly the song has a life of its own and is playing all over the mall - and the gang have become pariahs in their own hood. Jonsey takes a job as Wyatt's manager, but gets fired. And Jude tries to instill a new ""barter system"" in the mall by paying for things with Stick IT Kabobs and Gyros.
The Dust Bowl circus troupe deals with the fallout from a fatal fire and, in California, Brother Justin reaches new converts on the radio. Lila wonders what happened to Lodz. Ben takes off to find Scudder.
Terrorists take a passenger plane to Hong Kong hostage and three new members join Red Troop.