Ellenor continues her desperate attempt to stop the execution of a mentally ill woman Denise Freeman on death row. The firm is torn over a controversial settlement in their case against an alcohol company.
Nikki's efforts to get a loan are sidetracked when she and Professor Oglevee are taken hostage during a bank heist staged by a little person.
On a church ski trip chaperoned by perpetual party pooper Dr. Abbott, Amy and Colin share their first kiss since the surgery. Ephram finds himself intrigued by Colin's younger sister, Laynie (guest star Nora Zehetner), who has recently returned home from boarding school. Also, Bright attempts to get to the next base with his girlfriend (guest star Devon Reilly). Meanwhile, Andy hesitantly agrees to attend a singles mixer with the recently divorced Reverend Keyes (guest star Tim Dekay).
A nude man is found tied to his bed, having suffocated on a rag stuffed in his mouth while he was being sexually assaulted. Meanwhile, while investigating the murder of a crematorium owner, the CSIs discover dozens of bodies that were never cremated.
Spencer thinks that he has gotten a girl pregant and Dee Dee and Mona force him to get an AIDS test.
Flex's little sister, Bernadette has come to Baltimore to announce to her brother that she has given up her sucessful career in law to become a fashion model. Flex tries to figure out how to break the news to their dad. Meanwhile when Breanna gets a baby from her Home Economics class Josh and Arnaz become competitive to be it's father.
Maya befriends a fellow single mother, a janitor at the law firm's building. They quickly make a connection, but Joan finds the woman's attitude irritating; and fears that her example could negatively impact Maya's relationship with Darnell. Meanwhile, William pretends to work at Lynn's office because he misses the camaraderie of a workplace; and Lynn tries to scam her co-workers out of money by pretending it's her birthday.
Doug and Carrie photos get mixed up with another couples. When Doug and Carrie look at the other couples photos, they find out that their lives aren't as good as the others, so they try to do what are seen in the photos. Arthur's new cellphone is in no use when no one calls him.
Sydney, Vaughn and Jack must determine whether CIA agent Lennox is who he says he is after his deep cover mission is compromised.
Glen returns to Paige's life with a big surprise - he is about to get married to a girl called Jessica. Meanwhile, the sisters summon a Witch Doctor whom they want to dispatch all the evil remnants that surround the Manor.
The team races against time to find a crate of strontium which they believe will be used to make a dirty bomb. Lucy fears for her family when they are coming to her sister's wedding.
In the aftermath of his confession to Beth, JJ struggles to put their relationship back together again, but quickly realizes that it might be too little too late. Elsewhere, Meg strikes up a musical friendship with Sam as they decide to save money by sharing records - causing problems with JJ who quickly reminds his sister about the trouble she faced after her previous interactions with Sam. Meanwhile, Jack entrusts his new employee -- Nathan, the nephew of Henry with delivery duty, but later questions his decision when Nathan fails to return. Helen volunteers to baby-sit for her professor and gets to know him better while Roxanne fights for a coveted position writing the ""Backstage on Bandstand"" column for Teenzine magazine.
Marge gets mugged and becomes so traumatized that she develops Agoraphobia. She hides in the basement. Having little else to do, she decides to exercise with a weight set Homer bought from Rainier Wolfcastle's garage sale. She becomes so strong and confident that she is able to leave the basement. She continues working out and decides to start taking steroids so she can enter a bodybuilding competition. One night at Moe's Tavern she loses her temper and starts destroying the bar and fighting all of the patrons. Homer confronts Marge and says he misses the sweet woman that he married. Marge, horrified at what she has done, apologizes and decides to stop working out.
Johnny takes on a major corporation to prevent the mass marketing of a drug he foresees will cause terrible birth defects years down the line.
Everyone has a different opinion of new inmate Idzik; Alvarez receives shocking news; Redding's attempts at reform continue; Murphy makes a confession to Glynn; Morales'(David Zayas) medical suspicions are confirmed; and Beecher's devotion to Keller leads him into a perilous position.
Grandma Ida is even nastier than usual (if that's possible) because of a tumble down the front steps that resulted in a broken collarbone, prompting her to sue her daughter and son-in-law for pain and suffering. And there's more momentous news on the home front: Lois is pregnant.
After the tyrannical owner of a Manhattan luxury hotel is found submerged in her bathtub, evidence seems increasingly to indicate that the woman's death was the work of her deeply frustrated, long-suffering daughter.
Emma has been protesting GM(Genetically-Modified) foods for a long time, and she decides to take it to Mr. Raditch. When he tells her that the school can't afford it, and that they haven't been proven to be harmful, she decides to inform the students anyway. When Mr. Raditch finds out, he shuts down her informities. When Emma sees a documentary on the cafeteria, she tells the students to boycott the caf, but it ends up in a food fight, suspending Emma for the rest of the day. When she is interviewed for the Grapevine, she keeps going with her protests. Mr. Raditch gives her an ultimatum: Either apologize or be suspended for a week. She decides to keep going anyway. Spinner has his eye on a new designer shirt, but it costs too much for him. It's not enough that Jimmy is getting $1000 worth of stuff for a ''belated birthday present.'' When Spinner sees Jimmy's MP3 player, he decides to pawn it, ending their friendship.