Alan and Charlie are shocked when they wake up next to a strange woman, and try to find out what happened.
Haley returns to the stage and Brooke receives life-changing news. Meanwhile, Dan Scott returns to Tree Hill much to the chagrin of Nathan, who is about to sign a new NBA contract with the help of his agent Clay.
Following workers at the Pennsylvania SPCA, which rescues more than 10,000 animals each year, including domestic pets, and exotic and dangerous creatures.
After a wild night out, a teenage girl is brought to Princeton Plainsborough with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference, but things don’t go as planned when House’s private investigator, Lucas returns.
Jenny wants to be the Queen Bee of not only Constance but of all the Upper East Side, as she lands the hottest escort for the Cotillion. Meanwhile Dan and Vanessa try to convince Olivia to stay in NY by showing her the "true college experience". Leighton Meester's new single "Somebody to Love" is featured in the episode, along with performance from Plastiscines.
Lizzie finds herself in trouble after an incident at school, and Cassie's art may take her back to New York City for college.
Charles' career plans worry Cassie when he talks about joining the military, and Lizzie's budding thespian career may be cut short when the school musical is canceled.
Michael and Jeffery's kitchen is cramped, and their basement is dark and outdated. While Hilary works to fix their home, David struggles to find them a new home that meets their needs and fits within their unrealistic budget.
Erza asks Gray and Natsu to form a team with her to stop a corrupt guild from using a dark magic that has the power to sap the lives of everyone in Fiore!
Miranda gets overexcited by the prospect of her first real date and decides it's time to try to be more girly, but her makeover doesn't go quite to plan.
Horatio Caine calls Las Vegas CSI Ray Langston to come to Miami when a severed leg found in the Everglades is discovered to belong to a girl who went missing in Las Vegas a week earlier. The crossover continues on CSI:NY S06E07 Hammer Down (II) and CSI: Crime Scene Investigation S10E07 The Lost Girls (III).
The 1986 murder of a jockey is investigated after his body is discovered in a mass grave for horses. The victim disappeared shortly after losing a race that he had planned to be his finale before retiring.
Larry is forced to embrace his feminine side; Cheryl competes for a Seinfeld role; a law officer has an unusual name.
A well-meaning struggling writer decides to lead a sort of double life by pretending to be a private detective, using the methods he read about in old detective novels.
Dexter finds himself enjoying a brief moment of tranquility. He's finally managed to strike a balance between work, family... and other pursuits. But he's keenly aware that times like these aren't meant to last. When Miami Metro discovers a string of murders connected to a prominent photographer, Dexter sees an opportunity for a clean kill. However, his plans seem to be thwarted every step of the way. Quinn has taken a renewed interest in Dexter's nightlife. Dexter's plans to keep Astor and Cody distracted with new activities soon backfire. Even Harry disapproves of Dexter's choice of pastime, urging him instead to focus his efforts on the Trinity Killer. Meanwhile, Debra returns to work, frustrated to find everyone treating her with kid gloves. She decides to concentrate on her pursuit of the Trinity Killer as well as delving into her father's checkered past - investigations which Dexter fears might lead her to danger - or worse, the truth.
Hank's attempts to set things right with Karen lead to even deeper entanglements with the campus ladies. In the meantime, Charlie tries to prevent Sue's top client from leaving the agency and Becca scolds Hank for being a terrible role model for her.
Dr Martin Ellingham and Pauline are surprised by the number of patients coming to see him on the last day before his Surgery closes and he moves to London.
After Cleveland has "the talk" with Roberta, Cleveland Jr. becomes scared and takes a vow of chastity. Meanwhile, Rallo becomes a church greeter.