Michael threatens to cancel the escape plan unless he sees a proof that Sara is still alive. Whistler is accused of murdering an inmate and it is up to Michael to prove his innocence and save his life. Lincoln and Sofia help in monitoring the morning guards. Mahone may have another way to get out of Sona.
Returning to Stanford, the University that expelled him, Chuck has to help a former professor who is a government agent being hunted for a sensitive top-secret file he has in his possession. At the same time, Chuck learns much about himself and about the death of his friend Bryce Larkin.
Marshall and Lily's plan to buy an apartment is hampered by mistakes and Lily's hidden debt.
The infamous rapper Thugnificent moves to the neighbourhood with his friends Macktastic and Flonominal, eventually leading to Granddad becoming annoyed with his new neighbours. Their feud inspires Thugnificent to create a diss-track called "Eff Granddad".
Everything goes wrong for Michael as he tries to create a diversion. Lincoln tries to outsmart Susan who has his son. Sucre offers his assistance to Lincoln.
Barbara returns to town with news that could have Russell very happy.
Since Samantha has no memories of the past, including her sexual experiences, she is faced with the decision of waiting this time for the right guy to come along, or to experiment.
Kitty gets a visit from an old friend to do some damage control regarding her pregnancy. But it doesn't go as planned. Sarah is struggling with Paige, while Justin is down.
Lois and Peter sail off on a cruise. Jealous that he was left behind, Stewie's matricidal tendencies are rekindled. When Brian challenges him to actually do it, Stewie carries out his diabolical plan.
Zoey starts dating Dean Rivers' son. Meanwhile, Logan makes a dance video for girls so they can dance with him from the TV. Chase and Michael struggle to make 26 more cartoons for the end of the month, and end up getting sued by Friday Night Live for their idea of two bowling pins afraid of a bowling ball rolling towards them.
When Burbury, Connecticut is infected with a strange virus, Xavier must use his healing powers to save the town from an evil computer.
Michael goes after more power while he and Kath get ready for their little addition to the family. Tommy tries to fix the problems in a bad area of The Hill. Eileen learns from other politicians wives.
Palek's anxiety grows. Jamie must come clean with Nick. Katie receives some disturbing news.
When human remains are discovered at the bottom of a well, the team opens the 1938 case of a housewife who went missing the night of Orson Welles' radio broadcast of War of the Worlds.
Jen gets promoted to Assistant Coach at The Penalty Box, only to order too much wrestling merchandise from a marketing representative when she develops a crush on him. Jen needs to sell the wrestling gear while her job is still on the line, so Jonesy, in his Wrestling name "The Stud", lends a hand along with Jude and Wyatt as color commentators. Meanwhile, Nikki's ex-boyfriend Stone returns to the mall so Nikki tries to get over him, with Caitlin's help.
After a miserable ride to London, Ewan and Charley push on to France. Despite arduous weather conditions, they must stay on a strict time course.
Stan seeks out Francine's birth parents because her visiting adoptive parents annoy him so much. But they don't annoy Steve, especially after they give him fireworks.
Ben Stillman arrives at Heartland and his treatment of his horse Red angers everyone. Ashley lures Ty to Briar Ridge with a job offer.