One of David's closest friends is called into question after a man dies while boxing with him. When it turns out this is not the first time such an event has happened, things look even worse. Charlie is busy practicing what little he knows about poker, so he can take Larry's spot in a tournament.
Daniel reconnects with Grace Chin, a girl he once stood up for a date in college, and who is now New York City's top lawyer. Meanwhile, Betty befriends Charlie, an out-of-towner she meets at the Mode cafeteria, whom she later discovers to be Henry's girlfriend.
Kovac and Gates find themselves with a moral dilemma when a woman comes into the ER with acute liver failure; Neela finds herself questioning what is right when Manish decides to give up a kidney to a complete stranger. Meanwhile, Ray fights to get to the bottom of a cheerleaders accidental fall; Abby gets a prediction for her future; and Alex's troubles continue to intrude on Sam's work life.
As shocked as she is to be called the c-word by Lutz, Liz is more horrified to realize he may be right. Meanwhile, Jack brings Tracy to a charity golf event to get closer to the chairman, however his plan backfires when Tracy acts too much like his uncensored self.
Happy-go-lucky party animal Chris wakes up one morning to find his mum's gone away for a few days and left him a grand. But what do you do after you've thrown a party to end all parties and blown all the money?
Meredith is still underwater, but nobody seems to notice. Her worsening condition makes her rescuing an urgent matter. Derek finds her coat on a man she had helped, and starts looking for her and, much to his shock, the little girl Meredith took care of suggests that she is in the water. Derek saves her, but she is almost dead, due to hypothermia. Izzie has to perform brain surgery on a man stuck between cars, as he begins to experience seizures. She drills holes into his head, perforates his skull and ultimately saves his life before he is rescued and transferred to Seattle Grace Hospital. George lies to the woman whose son he had been looking for, in order to get to surgery, but still doesn't have any luck in locating him. Alex finds no hope in searching for the pregnant Jane Doe's family as she undergoes surgery. The interns find out about Meredith's situation and express their hopelessness. She wakes up in what appears to be limbo and meets her deceased acquaintances.
A boy named Tobias was blinded by the meteor shower but given the ability to identify other meteor freaks. Lex is using Tobias to locate other people with abilities so that he can perform experiments on them. Lana learns of Tobias and is fearful that he will name Clark as a freak, so she offers him a cornea transplant to keep him quiet. But Tobias has some surprising news.
The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.
Roy stopped by Pam's desk to let her know how excited he was to see her art show. She reminded him that it was just a small show being put on by her art class. Pam later admitted she was very happy she was back together with Roy because it showed maturity. Jim feigns indifference to the reconciliation.
Pixel has created LazyTown TV, a new TV station for the inhabitants of LazyTown to show off their talents.
The wife of an ultraconservative judge known for giving harsh sentences, who had also tried to have Sebastian disbarred twice, is murdered in an apparent robbery attempt at LAX. The judge becomes Sebastian's prime suspect when he learns the judge's marriage had been in trouble and he had been anticipating confirmation to the Federal Court of Appeals. Meanwhile, Julie plans a fancy dinner to say goodbye to Neal when she discovers he will no longer be her bodyguard.
A reality show where a group of contestants are stranded in a remote location with little more than the clothes on their back. The lone survivor of this contest takes home a million dollars.
Kelly, a member of the Solana staff tells Donald and Jacqueline that she is engaged to the sexy waiter Mateo. Maeto is then seen flirting with Kate.Having now got over the shock of Chantelle having a baby, Janice begins to bond with her daughter.Geoff and his mother do a duet at the karaoke.
Once he unseals a package sent to him through the mail, Grissom is floored when he finds a miniature crime scene inside. The finding is entirely more perplexing since the successive killer accountable for earlier related miniature crimes is now deceased. Grissom plows to examine the miniature and discover the actual location, when the investigation makes it clear the murder showed has yet to happen, but is probably going to happen soon.
In the immediate aftermath of a violent earthquake that rocks Newport, everyone struggles to stay together and keep their spirits up. Sandy and Kristen are stranded at the local shopping center where Kristen has an accident. Across town, Julie and Kaitlin are stranded in a demolished ice cream parlor on the pier with a pitiful worker of the place. Meanwhile, Ryan is seriously wounded with a piece of glass in his side, but keeps the news from Taylor to avoid panicking her. Seth soon learns of Ryan's condition and attempts to drive him to safety while Summer and Taylor search the ruins of the Roberts' house for Summer's missing rabbit, leading to Taylor having a confrontation with her mother.
Earl wants to use his birthday to look back on all the good he's done over the past year, but at his party, everyone seems to want to talk about his past misdeeds instead.
A Croatian Doctor comes to Sacred Heart, only to find out that he has to redo his Internship there. J.D. shows symptoms of 'Vasovagal Syncope', a condition that causes fainting and blackouts. Turk and Elliot argue over whose turn it is to take care of him, whilst Carla tries out her new excuse "I have a baby" and the Janitor takes a vacation.
Waking up from a dream that allows a mysterious woman calling herself Sandra to take possession of her body, Allison is freaked out and sneaks out of the house. Joe seeks Scanlon's help when her new identity refuses to leave her body.
After Desmond rescues Claire from drowning, Charlie gets Hurley to help him find out why Desmond has seemed able to predict the future. Desmond recalls exactly what took place in the moments after he turns the key, where he experienced a strange vision of his life prior to his Army days.
Haley confronts Brooke regarding the stolen calculus test. Lucas and Peyton consider taking their relationship to the next level as Peyton and Brooke grow closer. In Deb's absence, Nathan throws a senior party at the Scott House where a sex tape from Nathan's past surfaces.