Annie discovers that the particularly flirtatious mother of one of Lucy's friends, Serena is seeing Eric for therapy sessions. Annie strongly requests that he refers her to someone else. Annie then has to deal with the guilt over her jealousy-induced interference between the two. Also, Simon is mortified when word gets around school over the fact that he's a virgin. Annie had shared the details of Simon's sexual inexperience with his ex-girlfriend's (Sasha) mother, Rita. Meanwhile, Matt struggles about telling Robbie he's interested with his ex-girlfriend, Cheryl. Lastly, Robbie is also hiding a secret from Matt that involves his ex-girlfriend Heather.
Xena and Gabrielle become embroiled in a conflict between centaurs and Lord Belach, whose daughter has run off with one of the hoofed creatures. Xena has conflicted emotions, however, as Belach is the son of her past lover Borias and the centaur, Xenan, is the son of the deceased Ephiny.
The gang hits a local salsa club to help Nikki relieve some stress, but the outing winds up having the opposite effect when she sees Professor Oglevee with the school's new dean of students Toni Ross. Stanley runs into an old friend named Kenny Davis who becomes attracted to Nikki, but Nikki rejects all of his advances. Later, she becomes bothered by Andell's new relationship with Mel.
Rommie falls in love with a surviving android (Michael Shanks) of a destroyed ship, only to be betrayed as he turns out to be the ultimate enemy.
Marie gathers Robert's ex-girlfriends Amy and Stefánia and his police partner Judy, so they can dissect his character in an effort to help her better understand why her eldest son can't commit to a relationship. Unfortunately, Robert unexpectedly drops in and is forced by his mother to listen to his character being assassinated by the women as they discuss his relationship hang-ups.
Liz continues her investigation into Alex's death while Isabel plans her future and Maria wonders whether Michael will always be around.
Toni cheats on Greg with Clay and winds up contracting chlamydia. Joan frets about the fact that Sean has yet to tell her that he loves her, especially after he reveals that he has been offered a six-month job in New York. She seeks her friends' advice on how to coax a love declaration from him. Meanwhile, Maya feels threatened by the temp who filled in as Joan's assistant during her absence.
Larry defends Sting when a man sues him for breaking up his marriage; a Streisand impersonator sues over his nose job; Richard flirts with Cindy Margolis to make Ling jealous.
Sean, Jason, and Zack travel to the Big Island to participate in the Showdown 2001, a 12-mile course of natural obstacles. Leigh will be taking over supervisory duties at Baywatch while Sean is away. J.D. is tending to Kekoa, who has come down with the flu. Fortunately, J.D. has an iron constitution, despite the fact that he didn't have his annual flu shot.
State U. tradition has it that the first snowfall of the year means running around the campus...naked. To participate, Nitz realizes that he must lose weight, and fast. To spite his tyrannical RA, Gimpy leads his bands of nerd minions through a series of practical jokes in honor of Tekerson Tech Traditions Week.
Eugene and Jimmy agree to help the mistake-prone Harland Bassett (Ernie Sabella) in the case of a young girl who developed liver damage from an antibiotic. With the odds stacked against them, the trio take on a politically-tied, deep-pocketed drug manufacturer.
From TV Guide: ""To warn Sharique of the dangers of being an entrepreneur in the projects, Thurgood tells her about a cleaning solution he invented, Formula Forty-O Nine, and how a big corporation tried to take advantage of his accidental brilliance.""
In the throes of a hot session Brian gets upsetting news; Daphne asks Justin to be her first time; Ted wants Blake, despite his crystal meth addiction.
Pickles decides to quit smoking, but she replaces one addiction with another when she channels her nervous energy into becoming a reckless thrill-seeker. Her decision comes much to the dismay of Bob, who worries about her safety, and Milo, who resents her unseating him as the crazy one in the family.
Three old men from Yorkshire who have never grown up face the trials of their fellow town citizens and everyday life and stay young by reminiscing about the days of their youth and attempting feats not common to the elderly.
Mulder and Doggett are reluctantly thrown together to investigate several deaths aboard an oil rig, and Mulder becomes convinced that the rig is really carrying the black oil alien.
Fed up with all their demands and complaints, Julian tells everyone that he is leaving the trailer park. Ricky, who has been living in Julian's car on his front lawn, has one week to find a new place to live. Mr. Lahey, the trailer park supervisor, is thrilled to hear of Julian's imminent departure but when he hears that Ricky won't be leaving too, his worst nightmare seems about to come true.
Lois forbids the boys to ride a motorbike they found, but Reese disobeys and breaks a leg.
Homer's rush to the hospital to reattach his thumb, Lisa's rush to school to win the science fair, and Bart's run-in with an illegal fireworks scheme are interconnected in a parody of Go and Run Lola Run.
A somnolent visit with the ghosts of Christmas past lands Tony back on Melfi's couch. With the annual pork-store holiday party approaching, Bacala reluctantly agrees to don the Santa suit that Pussy used to wear. Tony and Furio have a holiday surprise in store for the Russian who roughed up Janice.