Max Cassidy vanishes after leaving a message on his wife's voicemail, with both Jack and Ann frantic to find him. While investigating, Jack realises that Max was having an affair, and that he's gotten much deeper into a case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team tries to hunt down Max.
One Survivor's attempt to forge an alliance is overheard by a lurking tribemate. A castaway is livid after a tribemate targets her for elimination in a Reward Challenge, which leads to an eruption back at camp. Paranoia fills the air, leading one Survivor to declare, "Everyone is lying, even the people you'd least expect!" Tribal Council is full of surprises when one Survivor takes advantage of the group setting to call out a tribemate. How will this influence the vote?
Another player is fired when the players face off in the fragrance industry.
Chris and Greg fall out when they break the rule of 'no computer games' after school at Greg's house. Back at the Rock home, Tonya is missing Chris as she can't blame everything on him.
Tulkinghorn is now close to piecing together Lady Dedlock's secret. Esther struggles to come to terms with the terrible blow she has been dealt. Jarndyce agonises over whether to keep his own feelings for Esther concealed. Lady Dedlock tells Esther something that will change her life for ever.
Andy tries his luck at a TV phone-in competition. Mrs. Emery visits the post office. Vicky starts her new job working on an adult chat line. Dudley catches Ting-Tong doing something unlady-like in the toilet. After another fight with bubbles, Diseree loses more than her towel. Linda assists with a course change for a female student with a slight facial hair problem. Majorie becomes jealous when her new boyfriend starts being friendly with Tanya. Daffyd introduces Myfanwy to his new... girlfriend? Mr. Mann is looking to buy a painting of a disappointed horse. Don takes Pat to an Indian restaurant, where the food has an unusual effect on him. Maggie is recovering well from a kidney transplant, until she's given the name of the doner. Sebastian serenades the PM in the Houses of PaliamentAndy decides to make a trip along the River Thames slightly more interesting.
The Doc deals with a strange family who seem reluctant to let him make house calls, and whose passion for taxidermy seems to hint at a dark secret involving their missing mother. PC Mystow also has family problems when his overbearing sister moves in a sets up shop - much to the Doc's disgust - as a herbalist. A chance remark by Pauline sets Al on a path that could well destroy his relationship with Bert.
Jude finds himself a new goldfish friend named "Fish". Meanwhile, Nikki snaps at Caitlin, after Caitlin keeps telling stories to her friends about her new crush, Wade, which leads to Caitlin and Nikki being no longer friends. After the gang is forced to take sides they try to get Nikki and Caitlin back together.
Gina is planning a family Thanksgiving. Joey and Zach discover some ancient Native American artifacts on Joey's property and mistakenly give them away.
Mac, Danny and Lindsay investigate the death of owner of a doll hospital. Stella and Hawkes look into the death of a woman with terminal cancer.
Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.
The deaths of three women with the same name lead Fontana and Green to the nine-year-old conviction of Leland Barnes, who had shot and killed his wife in an office full of people. With two of the three witnesses against him dead and Jack McCoy on the hit list, the detectives struggle to determine how Barnes, who has been in prison the entire time, got someone on the outside to kill the only people who could keep him in jail. The investigation leads them to Leland's two sons, with surprising results.
When Xana possesses Kiwi, it turns the little dog into the carrier for a virulent virus that turns those it infects into zombies. To make matters worse, Aelita and Jeremie are stuck in the cafeteria and can't get to the factory. On top of that, Odd is a zombie himself. Jermie and Aelita escape but Ulrich and the other students (except William, who is turned into one himself) fight the rest.
Kim and Christine are unusually attentive to Greg and Jimmy after spending an evening listening to a critical husband constantly belittle his wife. The girls don't want to spend any more time with the couple, but Greg and Jimmy encourage the relationship in hopes that their good fortune with their wives will continue.
Russell is suspected of committing a double murder. Larkin discovers Russell's criminal history and wonders about who he really is. Mariel insists that she saw a body in the water and demands that the bay be dredged.
Veronica helps Keith determine who is haunting a school bus crash victim's parents, currently embroiled in a suit against the school district for negligence.Meanwhile, after Logan asks for help fighting the murder charge against him, Veronica stumbles
Elle, along with many others, is held hostage on a train in Texas by a paranoid schizophrenic who is convinced that the U.S. government is monitoring him. Hotchner and Gideon are forced to play into the man's fantasy to save the people he has taken hostage.
Violence erupts when Ana Lucia and her group stumble upon Sayid and the other castaways on the island. Ana Lucia holds Sayid captive. Kate and Jack care for Sawyer when Mr. Eko brings him back to the camp himself. Flashbacks reveal Ana Lucia's troubled life as a cop.
On 26 September 2000, waves push the MS Express Samina off course, causing it to hit a group of rocks off Paros and sink, killing 80 people. The ferry was on autopilot, with the crew not monitoring the ship's course. They were instead watching an association football match. Note: This is a Crash Scene Investigation episode.