Vanessa uses the scandalous picture of Catherine and Marcus to blackmail Blair into being a nicer person, so Blair seeks revenge by enticing Chuck to seduce Vanessa. Lily and Bart throw an extravagant housewarming party and expect their children to make them proud in front of the attending press, but a rebellious Serena isn't ready to play by their rules. Meanwhile, Dan and Jenny discover a big secret that Nate has been keeping from his friends.
Alan and Shirley prepare for a fight with the military on behalf of a man whose brother died under suspicious circumstances. Meanwhile, Jerry helps his sister in her search for the identity of the father of her son, who was conceived through an anonymous donor.
Charlie tries to help Jake's former teacher, who became a stripper after dating him, but things go from bad to worse when she has a religious conversion.
Villains Knox and Daphne are on a quest to recruit Hiro and others to the Pinehearst fold. Angela and the Company are paralyzed from recent events. Peter goes to Pinehearst searching for answers but is stunned to learn who the founder is. Claire and Sandra go on a mission to save Meredith from the clutches of Doyle, a villain with abilities to control people mentally and physically. Nathan and Tracy try to trace their origins with Mohinder's help.
Tim and Tarquin's family has outgrown their house. The lack of bedrooms and angled walls on the main floor have them wondering what to do. Designer Hilary and Realtor David want to help the family with their housing problems. Hilary and her team will renovate the major problem areas of the house to make the family love it again. David will search for houses that will convince the family to leave. And after all the work is finished, Tim and Tarquin will have to make a decision about their house. Will they Love It? Or List It?
Lauren and Audrina travel to Cabo for Brody's birthday, but Audrina's problems with Justin threaten to ruin the festivities. Back in LA, Spencer gives Stephanie's new boyfriend a hard time over dinner.
A fraudulent astrologer named Martin Trueman is hit by an extraterrestrial body and begins to impress everyone with his uncanny predictions. However, what he predicts for Sarah Jane is far from pleasant...
The new Sam decides to take a trip to Africa in hopes of providing some help to people who desperately need it, but then chickens out when she finds out what it's going to take to get there.
A 43-year-old man takes a nap at his parents house, and is later found dead in bed. The man had several conditions that put his health at risk, including morbidly obesity, high blood pressure, and sleep apnea. However, Dr. G is hesitant to jump to conclusions when her autopsy findings dont quite add up, so she opts to wait for the toxicology results before closing the case. A 53-year-old woman is found dead on her couch. The woman was obese and a smoker, her son notes that she had suffered an episode of intense eye pain the day before, and Dr. G finds signs of trauma on the womans lower body. With many potential suspects, only Dr. Gs autopsy will narrow down the cause of death.
Nora gets ready for a new charity venture by getting rid of all of William’s belongings. Meanwhile, Robert begins to interview possible replacements for Kitty; Holly looks into the location of William’s son; and a time capsule brings two of the siblings closer together.
Mort Goldman accidentally steps into Stewie's time machine and goes back in time to 1939 Poland, and Brian and Stewie follow to retrieve him. When they find him, the Nazis invade and Mort is taken to Germany, where Stewie and Brian must go to save him, as well as find a way back to the present.
Jane develops a passion for football and is interested in playing on the school team. However Degrassi's only option is to play on the boy's team. Which leads to several unexpectedly mishaps.
Hank and the guys do a good deed when they fix-up a neighborhood house, however after Ted Wassonasong buys the house he decides to knock down the house and build a mansion.
Vince gets a taste of the fashion world when he agrees to do a Dolce & Gabbana photo shoot with a gorgeous supermodel. Ari pays his respects at a funeral while he tries to work a deal for Vince.
Lt. Colonel John Sheppard's team is invited by the Coalition of Planets in order to form an alliance. However, the team is misled and is faced to stand trial, for their alleged crimes against the Pegasus galaxy. Their best chance of freedom, is the experiences of Richard Woolsey.
Bob and Mac both find themselves in trouble when they each take assignments undercover. Bob as a chemist who hides cocaine by converting it to paint and Mac as a fighter trying to bust an illegal betting ring.