Derek and Meredith try (unsuccessfully) to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bailey, who warns Meredith to end the relationship. Meanwhile George suspects an anesthesiologist of drinking on the job but is reluctant to speak up about it, Alex treats a former competitor who now finds honor in self-mutilation, Izzie has to deal with a patient who won't let go of his girlfriend - literally, and Cristina seems to be battling a case of the flu.
Brian becomes a substitute teacher at Chris' school after his teacher wins the lottery. When Brian is moved to teach a class of troubled kids, Chris falls in love with his new teacher, Mrs. Lockhart, who promises to love Chris only if he kills her husband. When Lois finds out, she and Stewie decide to teach Chris a lesson.
When Hal decides to attend his first annual Neighborhood Association meeting with Malcolm, he is strongly encouraged to take on the role of President. Being his dad's right-hand man, Malcolm sees a perfect opportunity to add some excitement to the community, while Hal's agenda is a little bit different. Meanwhile, Francis takes on a new job as a camp activities coordinator and turns to Dewey for his input on some creative new games. While Dewey revels in his afternoon of fun, his fed-up classmates take their teacher, principal and janitor hostage.
Cochran's ominous prognosis puts the camp on alert. Smallpox survivor Andy Cramed returns as a minister. Swearengen asks an unlikely pair to pull a scam on Commissioner Jarry. Martha Bullock has second thoughts about staying in Deadwood.
Hayley comes home from a Green Party rally with her hair dyed green, instigating a fight with Stan. While she's sleeping, Stan cuts her hair (for her own good, of course). After learning of what Stan did, a wigged Hayley defies her father yet again by moving into the van of her new boyfriend. When Stan cuts her off financially, she gets a job as a waitress in a strip club, which pushes Stan right off the edge. Meanwhile, Steve tries to pass Roger off as his disfigured sister in order to cop a feel with a female classmate.
The boys find ways to help Ray now that his trailer has burned down. Bubbles realizes that the fire was not his fault.
Bette reaches out to Tina as she decides to take her father home for his final days. Jenny struggles after recalling a difficult memory from her childhood, and Alice becomes jealous when Dana agrees to have dinner with her ex-girlfriend, Lara.
After a young actress is gunned down after an evening out with her boyfriend, Goren and Eames initially focus their attention on a young man who had showed an unusual interest in the couple, but soon realise that there is more to this case than meets the eye. A jealous and seemingly obsessive ex-girlfriend, a best friend who never made it as an actor, and a grieving boyfriend who seems too good to be true lead Goren and Eames down another path, one where the key to exposing the truth about the present depends on exposing the lies of the past.
Nigel is spending the evening with his new soul mate when her daughter ends up kidnapped. Nigel is left with questions that science cannot answer. A man thought to be dead awakens on the autopsy table…scaring Lily.
When an old truck containing human bones is pulled from the Delaware River, the team re-opens the case of a missing and possibly murdered girl who disappeared unexpectedly in 1932.
Hank talks Bobby into joining the track team, but the spot the boy lands isn't what Hank had in mind.
Jonesy becomes the manager of a guru. When the guru is unable to come to the mall for his speech, Jonesy gets Jude to take his place. Jude gives people his ridiculous advice, leading to catastrophic events with Wyatt stuck up a ladder when he is afraid of heights.
Three old men from Yorkshire who have never grown up face the trials of their fellow town citizens and everyday life and stay young by reminiscing about the days of their youth and attempting feats not common to the elderly.
A young boy is shot at the Hall and Lord Ashfordly comes under investigation for employing child labour - but Bellamy discovers that the truth is rather more complicated. Peggy turns her hand to the tourist industry.
Unbeknownst to the sisters, baby Wyatt's new ""imaginary"" friend is actually a demon named Vicus who is trying to win Wyatt's trust to turn him evil. Meanwhile, Piper casts a spell to be able to understand baby Wyatt, but inadvertently brings 25-year-old Wyatt back from the future.
Sue meets a woman who says she saw a murder but the only problem is there are sure whether Beth heard or saw the murder. Sue and Jack find out that their witness is schizophrenic and gives them clues in strange metaphors making the case all the more complicated to figure out. Also the team gets a new acting supervisor named Wayne. Their new supervisor begins to drive them crazy when one begins to color code all their cases. He places the current case as a low priority case. They soon find out that Wayne has never even solved an FBI case in his life.
Adam catches a glimpse of the wonders of travelling in the Tardis, as they head to a future, where Satellite 5 broadcasts to the entire Earth Empire. But anyone promoted to Floor 500 is never seen again, and the Doctor suspects mankind is being manipulated.
The SAS is sent to Chechnya to find rebel leader Movzar Mazayev. Henno mistrusts Russian Special Forces agent Vasily who is assigned to help them. The soldiers close in on Movzar's fiery sister Sapiyat but intelligence officer Kathy is taken hostage. In this conflict where political ideals and personal tragedy overlap, can Red Troop bring down their targets and rescue Kathy? This episode also features the Battle of Galashki