Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.
Lisa agrees to enter a Krusty-sponsored "Li'l Starmaker" competition and panics when another contestant (guest voice Fantasia Barrino) outperforms her.
Derek and Meredith try (unsuccessfully) to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bailey, who warns Meredith to end the relationship. Meanwhile George suspects an anesthesiologist of drinking on the job but is reluctant to speak up about it, Alex treats a former competitor who now finds honor in self-mutilation, Izzie has to deal with a patient who won't let go of his girlfriend - literally, and Cristina seems to be battling a case of the flu.
Brian becomes a substitute teacher at Chris' school after his teacher wins the lottery. When Brian is moved to teach a class of troubled kids, Chris falls in love with his new teacher, Mrs. Lockhart, who promises to love Chris only if he kills her husband. When Lois finds out, she and Stewie decide to teach Chris a lesson.
When Hal decides to attend his first annual Neighborhood Association meeting with Malcolm, he is strongly encouraged to take on the role of President. Being his dad's right-hand man, Malcolm sees a perfect opportunity to add some excitement to the community, while Hal's agenda is a little bit different. Meanwhile, Francis takes on a new job as a camp activities coordinator and turns to Dewey for his input on some creative new games. While Dewey revels in his afternoon of fun, his fed-up classmates take their teacher, principal and janitor hostage.
Cochran's ominous prognosis puts the camp on alert. Smallpox survivor Andy Cramed returns as a minister. Swearengen asks an unlikely pair to pull a scam on Commissioner Jarry. Martha Bullock has second thoughts about staying in Deadwood.
Adam catches a glimpse of the wonders of travelling in the Tardis, as they head to a future, where Satellite 5 broadcasts to the entire Earth Empire. But anyone promoted to Floor 500 is never seen again, and the Doctor suspects mankind is being manipulated.
The SAS is sent to Chechnya to find rebel leader Movzar Mazayev. Henno mistrusts Russian Special Forces agent Vasily who is assigned to help them. The soldiers close in on Movzar's fiery sister Sapiyat but intelligence officer Kathy is taken hostage. In this conflict where political ideals and personal tragedy overlap, can Red Troop bring down their targets and rescue Kathy? This episode also features the Battle of Galashki
Batman investigates a villain known as Clayface, who is able to transform into other people.
After trapping Chase Young in the Sphere of Yun, Jack and his newest partner, Cyclops, take over his lair. He then proceeds to attack the Xiaolin Temple, stealing Shen-Gong-Wu from the vault. Omi later frees Chase using the Reversing Mirror, returning the 'favor' he owed him from earlier. The other Warriors do not know Omi freed him. Chase slowly tries to mold Omi into the true evil warrior he knows the young monk will become.
Chase Young is looking for an apprentice. Either Katnappé or Jack will be able to win it. Katnappé has reprogrammed the Warriors' U-bots to be evil. Master Fung informs the Warriors that their new threat is Chase Young, and he must teach the four monks to be deceptive in order to triumph. However, Omi is too trustworthy. After Chase chooses Katnappé to be his apprentice, Jack turns to the Warriors and asks to join the side of good. Omi trains Jack the best he can to release all the evil that is inside of him, but after Katnappé attacks the Temple, Jack takes off with the Warriors' Wu, which tests Omi's trust.
Hot Shot takes a dangerous gamble in the next round of the Speed Planet Cup, while Sideways tries to pit the Autobots against the Decepticons against each other...
A xenophobic faction of humanity threatens to undermine talks to form a new coalition of planets.
Maddie has her prom at the Tipton Hotel after realizing there is nowhere else to have it. Zack thinks that he will be her date, but ends up getting dissapointed. Cody starts to act like a mime.
Numbuh 5 goes to the planet Mars to pick up some marshmallows as part of dessert with her family after dinner. But upon her return, she discovers her family and friends are being menaced by an old foe who now is a mere shell of his old self.
When Mac accidentally imagines another friend, Bloo suffers sibling rivalry with the newly arrived and very odd Cheese.
Don and Agent Weston of the NTSB investigate eyewitness accounts of a mysterious unidentified object flying dangerously close to downtown Los Angeles that has raised concern of a terrorist attack. After Charlie is recruited to help with the investigation, it is discovered that the flying object is part of a new technology that could revolutionize air travel. But the investigation takes a turn when they learn that the lead engineer is found murdered.
Plankton unleashes a new plan; to get the Krusty Krab to work 24 hours. SpongeBob thinks this is a dream, until he thinks he is being chased by killer Krabby Patties.