Jay is ready to graduate from college, but a series of events ruin her appearance.
Nathan's Uncle Cooper comes into town to take Nathan and Lucas on a racing trip. On the track, Nathan and Lucas are challenged to a race by the beautiful Daytona and her smart aleck brother Jarret, but things go horribly wrong when Nathan loses control of his car and crashes into a wall. Meanwhile, Deb's addiction to pain pills intensifies and Dan exposes Andy's relationship with Karen to his class.
Mickey's got a plan and this one is like no other. They're going to steal the Crown Jewels. Will he be able to get the others to join him on such a dangerous mission?
Krypto and Ace take on a mutant dog-plant hybrid who is stealing all the trees in Metropolis.
Mona entertains overtures from the head of a rival record company, who hopes to hire her away from Delicious. She seeks her father's advice on how to handle the situation, leading to resentment from Phyllis. Meanwhile, Big Dee Dee plans a lavish 15-month ""birthday"" party for Drew in the hopes of showing up her friends.
Ray's latest manipulative plan involves constantly turning down Debra in the bedroom.
Mary meets her secret admirer but faces legal issues on the road to romance. When a philandering hotel guest (guest star Dave Foley) loses his wedding ring at a local brothel, Mike agrees to help him find it by investigating the establishment. Meanwhile, Danny and Ed do some investigating of their own to respect a friend's last wish for justice.
Gigi decides that a new bed – one her ex-boyfriend hasn’t touched – will be the only way to start fresh in her love life. While her friends Stella and Francesca are off bedding porn stars and movers, Gigi continues her search for a new mattress, and a new man to test it out. Unfortunately, her new bed is soon broken in by a howling ex-pimp. To make matters worse, while mattress-shopping, Gigi bumps into her ex-boyfriend and his new girlfriend who happen to be purchasing a bed for their new shared room.
Jake's visiting accountant brother Brian (guest-star Tom Parker) from LA says he sees no future for Jake and Nina, prompting Jake to seek advice from Andy. Also, accepted at Princeton, Amy assumes that her father secretly sent in her application. Lastly, health issues create tension between Rose and Harold, but the tension turns to fear when Harold finds out that Rose has a 3-centimeter long tumor.
After a bitter custody battle, shots are fired outside the courthouse. Bullets fly and the target is the little girl's mother. Horatio goes after the father, who he suspects may not be the girl's biological father after all. However, when the mother's shady past is uncovered, the team finds that she has a lot of enemies who would like to take a shot at her. Meanwhile, Calleigh's father returns to the crime lab for her guidance but for an unexpected reason.
When her boyfriend cancels their date for the senior party because she won't have sex with him, a depressed Spirit gets drunk on way to the event and misses all of the festivities. Meanwhile, Danielle and Candy are convinced they are being stood up by their dates with Flex and Duane, but unbeknownst to them, the guys are being held up at gunpoint by a man (Chingy) down on his luck.
After sleeping with bandmate Finn, Lynn believes that she can deal with an open relationship, but becomes extremely jealous whenever she sees him with other women. Meanwhile, Joan forces William to attend Toni's baby shower, although he believes such events should only be for women. He gives Toni an heirloom cradle that he expects to get back in the future for his own kids, only to learn that Toni has given it away to her cleaning lady (before firing her).
After Logan authorizes Palmer to take charge of the crisis, Palmer sanctions Jack and Curtis to infiltrate the Chinese Embassy on a covert operation to capture a suspect. Tony and Michelle continue to bump into each other's personal lives, while Buchanan expresses anger at being kept out of the mission. Jack faces Audrey's wrath when a medical dilemma places Paul's life in jeopardy.
When a case from ten years is re-opened, Allison finds herself in a chaotic situation. Things continue to get messier when Allison finds out that the convicted man is innocent, and that someone she knows and trusts may have been involved in his framing.
Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.
The Simpsons' roof springs a leak when the perfect storm hits Springfield. And when Marge asks what type of father can't keep a roof over his family's head, Homer tries to fix things up, but falls through the roof. Sick of being unwanted, Homer befriends a man who works as a roofer. However, no one else can see him and Homer's insistence that the roofer does exist prompts everyone to think he has gone crazy.
When Bart endangers his health by bingeing on vending-machine food, the Simpsons turn their home into a hostel in order to afford sending him to a forced starvation facility.
Peter and Lois decide to go on a second honeymoon. But when Peter crashes the car, he decides to pose as Mel Gibson to stay in his fancy hotel suite, where they find a copy of a "The Passion of the Christ" sequel. They attempt to destroy the film and end up being chased by two priests who went to retrieve the film.
Izzie tries to get George to find the courage to ask Meredith out. All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship is also getting more complicated...