Kelso drops Jackie off in Chicago, but she is immediately homesick and reaches out to the gang for companionship. Eric finds out at the last minute that Kitty deliberately hid a letter outlining the vaccination shots he’s required to have before going to Africa for the year. He has his final Circle with the guys only to finally be busted by Red! As Eric says his good-byes to everyone, Hyde talks to Leo about his true feelings for Jackie and decides to follow her to Chicago…with disastrous results.
Nathan is released from the hospital and returns home to a pile of unpaid bills and an eviction notice. Lucas, Peyton and Brooke throw a fundraiser Tric to raise money, but Dan is the one that comes to Nathan's rescue. However, his gift comes with strings - he wants Nathan to ask Haley for an annulment.
After careful observation of Professor Avalon, Techna and Digit become convinced that he isn't who he says he is. They begin researching his past and fear he is the Angel of Doom in disguise.
After a woman's head is found in a car junkyard, the detectives track it down to the black market.
Jim uses all his manipulative skills to get himself out of jail, but will Di realsie he is using her? Everyone on G-Wing is up in arms about the extortion racket Natalie Buxton and her sidekick Darlene Cake are running. Jim blackmails Neil Grayling into giving him the Wing Governor's job, and starts by sacking the two Julies from the kitchen. Phyl and Bev jump at the chance to replace them, but they're unprepared for all the hard work. Sylvia is sure that she has a mysterious illness - Dr Nicholson is unterested until a letter arrives for Sylvia...!
George steps in to be Jason's sports agent when NFL Quarterbacks Daunte Culpepper and Donovan McNabb (guest starring as themselves) pay a visit to the Lopez household to draft Jason for their alma maters and a minor league baseball recruiter approaches him for a contract. Meanwhile, Carmen and Los Lobos guitarist Cesar Rosas stir things up at George's family birthday bash.
Michael buys an R.V. and the family heads to the Grand Canyon for a vacation.
Jay asks Michael to get a vasectomy, but he says no. Eventually he tells Jay that he will go through with it, but then backs out at the last second. Jay says that she will instead get a hysterectomy. After she comes out of the clinic, Michael tells her that he will get the vasectomy, but she then reveals that she is pregnant.
Lorelai rescues Rory after a night of reckless behavior. Shocked to hear her daughter's plans for the future, she turns to Luke for help.
Monica orders her units to turn the streets of Farmington inside-out when two officers mysteriously disappear after answering a 911 call. Shane tries to make amends with his old crew after Vic agrees to help him get out from under Antwon, but things don't work out as planned. Dutch and Claudette convince Monica to let them take active roles in the case of the missing officers, but soon find themselves at a dead end with the only witness being clinically insane.
House must decide whether to take the case of his ex-love's husband and he gives medical students a lecture they'll never forget.
Jack finds that his efforts to bargain with Marwan for the location of the missile strike are futile. Heller pushes his son for information when CTU discovers that he may have had contact with Marwan before the attacks. Logan finds himself in the middle of a power struggle between Palmer and the ambitious Speaker of the House. Tony and Michelle explore their rekindled passion for each other, but their hopes for the future may be short-lived when a familiar player enters the game and takes a hostage.
In the hopes of getting closer to Phyllis, Dee Dee sets her up with her bitter divorced professor. However, the relationship soon fizzles, and the professor seeks revenge against Phyllis by turning her in for having too many cats. Phyllis blames Dee Dee, whose efforts to correct the situation only wind up making it worse.
In 1996 a beautiful newlywed, was attacked and left for dead. The only thing taken was her wedding ring and she has been in a coma ever since. The man jailed for the crime is now a born-again Christian and is protesting his innocence
Ephram prepares to leave for Europe as he feels that he has nothing left for him in Everwood. However, he's caught off-guard and questions his plans when Andy reveals the secret that Amy has been keeping from Ephram. Meanwhile, Nina and Jake contemplate going into business together, but the stress on their relationship proves a big obstacle to overcome. Meanwhile, Bright finally confesses he has feelings for Hannah.
An axe murderer on death row is given a stay of execution just moments before it was to take place, on the grounds that there may have been tainted DNA analysis used at his trial. Now, without using any DNA evidence, the team must race against time and reexamine all of the physical evidence in the case, just as they get a call on a new double murder that looks suspiciously like the case they're working on.
With graduation quickly approaching, Flex's ex-wife Nicole (Tichina Arnold) convinces him to meddle in Breanna's love life, hoping she will choose a college in California over staying in Baltimore with Arnaz. Later, Arnaz tells Breanna that she should go to California to follow her dreams, but she thinks it's his way of breaking up with her.
After Darnell reveals that he has failed to get a band for his wedding (which is just two days away), Maya recommends that he hire Lynn's band. However, Lena is not impressed after hearing the group perform, and lashes out at Darnell. He turns around and blames Maya for the fight, accusing her of trying to sabotage the wedding. Darnell shows up at Maya's apartment drunk after the bachelor party and says that he loves her. Meanwhile, Lynn continues to battle her feelings of jealousy regarding Finn. William begins to complain about the restaurant, prompting Joan to suggest that he is actually dealing with issues about their break-up. After going into false labor, Toni vows to live life to its fullest in the short time left before she gives birth.
Gigi is pulled out of her depression when a call from her agent brings news of a job – a gig for a cable network movie shooting in the Rockies. Not realizing she is merely the movie’s required Canadian content, Gigi ventures north in search of a break from Los Angeles and her ex-boyfriend Payne. Her wish comes true when she meets (and beds) Bo, the Olympic bobsledder – only to find out later he’s an anti-Semite.
Ray fears getting his adenoids removed, but Debra convinces him to go through with the surgery. At the hospital, while Marie is in the bathroom, and everyone else in the waiting room, the nurse comes out and tells Debra that Ray isn't waking up from the anaesthesia.