After receiving a message containing clues on Tweetums' whereabouts, the Loonatics and Sylth Vester seek out where Tweetums is. Meanwhile, General Deuce and Optimatus begin their plans to conquer the universe.
When SG-1 discovers that Daniel Jackson has been turned into a Prior of the Ori, they must determine whether or not his plan to destroy the Ori is genuine.
Steve is given an opportunity to live life as a 'street madman'.
Bloo sees a sci-fi movie about extraterrestrials that look like Cheese, so he thinks that Cheese is a brain-sucking alien.
Robby, tired of refereeing Jackson and Miley's latest feud, puts the skids on his kids' weekend plans. When Miley and Jackson make a break for freedom, the pair's bickering leads to a bigger problem. Will Jackson's actions finally make Miley smile?
Green and Cassady follow the leads when a young boy is found murdered to a suspected serial pedophile/murderer.
Don, Charlie, and the team take on unknown terrorists who may be using nerve gas to undermine Los Angeles' water supply.
A Neuro who can see the future warns Jane and the team of their impending death on the day they arrest him. Meanwhile, the team is disturbed by the psychic's purchases
Five accidents, and four signs, something else is going to happen. Melinda becomes concerned for the safety of the people she loves when a ghost prophet shows her visions of the future. The fellow Ghost Whisperer, who Melinda doesn't trust is still in Grandview.
It's Ruby's birthday and Ruby expects her friends to throw her a surprise party at their home. But Ruby must give chase when Max makes off with her birthday tiara.
Jeremy meets his hero, techno musician Russell "The Orgazoid". He ends up working as his handyman, which leads Mark to become suspicious, as it seems that Jeremy's job consists of making smoothies for him. Meanwhile Mark meets Sally at his school reunion, one the few girls who actually ever liked him. It turns out that she has married one of Mark's childhood tormentors, Foz. Mark decides to try and seduce Sally whilst Sophie is away on a business trip.
Betty struggles with a dilemma as she attempts to bail her family out of a financial crisis while juggling with the task of planning MODE's big assistants week at a medieval-themed restaurant...where Amanda's past ties to the establishment has a link and could come back to haunt her in a surprising way. On the romantic front involving the Meade siblings, Betty tries to give Daniel advice about his endless sexual addiction, while Alexis ponders about whether she should start taking up Rodrigo's offer. Meanwhile, Hilda prepares for her first exam to determine her future at cosmetology school as Wilhelmina prepares for her future plans to take over MODE as she makes even bolder moves for domination behind the scenes.
What is suppose to be a departmental dinner organized by Kovac turns out to be the surprise of a lifetime for Abby when she soon learns it's a surprise wedding, secretly planned by the eager groom. Meanwhile, at the wedding, ER staffers enjoy themselves with music and booze while Neela finds herself the center of unexpected attention between Gates and Ray, which leads to a drunken fight and a shocking conclusion.
The quest for the Enchanted Honey concludes when the gang arrives at Amber Castle, which is the home to a hive of Combee and their leader, Queen Vespiquen.
Xzibit and the boys at GAS transform a 1981 Mercedes-Benz 300SE from clunker to "crunker".
An old friend of Stark is back. But this time, Stark gets a second chance at justice when he puts Wayne Callison on trial for another murder. Because of the exact same wounds as the previous victim, Callison is accused of murdering another young woman.
A reality show where a group of contestants are stranded in a remote location with little more than the clothes on their back. The lone survivor of this contest takes home a million dollars.
When Earl decides to get his first real job at an appliance store, he experiences 'growing pains'. Meanwhile, Joy makes another irrational decision when the forthcoming trial continues to get to her.
Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.
Lana and Lionel have a secret meeting, after which Lana is shot. While Jimmy is observing photos of the encounter, he is knocked unconscious. While unconscious Jimmy dreams about what life in Smallville would have been like in the 1940s. Clark is a reporter at the Daily Planet, Lana is a siren who planned the demise of her magnate husband Lex, and Lois is a singer at a bar that Lionel owns.