A sportscaster becomes a full-time dad when his ex-wife decides to accept a job out of the country and his teenage daughter, Breanna, moves in with him.
Maya hosts a seminar where the girls participate in a panel and one of the attendees begs Toni to be her mentor. Kelly Rowland guest stars.
Tina takes a business trip to Canada and has a chance to explore her feelings for the opposite sex. Dana's treatment puts a strain on her and Lara's relationship. Meanwhile, Jenny helps Moira in her transformation to Max, Carmen and Shane dedicate parts of their bodies to each other, Alice reverts back in her obsession over Dana, and Kit takes control. In a special appearance the B-52's perform at The Planet.
Nikki falls for a new guy named Stone, while Jonesy is beaten by a twelve-year-old at an arcade game.
When Riley's affinity for grafitti goes too far, Grandad sends him to an art teacher that actually encourages him to do grafitti, only painting murals instead. Meanwhile, Huey discovers a black woman died from watching too much black TV, and decides to watch black TV for 2 weeks to see if that was the cause.
Paige learns the difficulties of dating a mortal when Henry becomes too involved in the magical world and is torn when another suitor arrives hoping to convince her to marry him so they can become the ultimate magical couple. Meanwhile, Billie finally finds her missing sister, Christy; Piper faces a romantic decision when she runs into an old flame and begins to wonder if she should move on with her life.
Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.
Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.
Hal learns that his father has passed away, but sheds no tears and passes it off as nothing since he never knew him. So, to make sure nothing like that happens again, he lets the boys do whatever they want by letting them miss school and even offering to buy Malcolm a new car, until Lois puts a stop to it. Noticing how depressed Hal has become, his friend Abe brings George Takei over for a visit in an attempt to cheer him up.
Orel learns that people should do everything they can to keep their wives happy. He goes around town and asks women including his mother, what they want.
The League comes to the aid of Boston Brand, the ghost of a deceased circus acrobat, who needs their help in recovering the souls of members of a monastic order.
While helping to create a memorial garden for a woman who intends to re-marry her former husband, Rosemary and Laura are surprised to find an abandoned baby under a gooseberry bush. While the pair wonder who the mother is as they get on with the garden, a gunshot soon leads them to the body of a noted artist, leaving them wondering if the murder and the abandoned child are possibly connected...
Maximillian Zeus, a millionaire who is also a Greek history fanatic, takes control of Gotham from the sky after losing to Mayor Grange in a re-election.
Bishop has too deal with the consequenses of his actions when people and animals all over New York starts mutating into horrible beasts after his "alien" invasion.
The Loonatics take on an old enemy of Tech: Mallory Mastermind. When Mallory escapes from prison, she swears revenge on Tech. It will take all the genius Tech has to defeat this genius of a foe.
Hannibal Bean gets into Omi's head while he is sleeping and tells Omi that he should take all the Wudai Warriors elemental Shen-Gong-Wu and master the power of the elements to become the Xiaolin Leader. The whole thing was a set plot for Hannibal Bean, now will Hannibal Bean destroy Omi and take his elemental powers, or can Omi stop Hannibal Bean before it's too late?
Josh gets a part on a TV crime show where he plays the infamous "Theater Thug." Following his TV debut he becomes a public enemy as a case of mistaken identity gets out of hand.