Rory, Lorelai and their beaus spend Valentine's Day weekend on Martha's Vineyard. During their stay, Rory's boyfriend saves the day.
Sam and Dean head to Minnesota where a young boy witnesses a man vanish into thin air. Upon searching for clues, Sam is abducted by what he assumes is a supernatural being, and Dean is left to search frantically for his brother. However, both are stunned when they realize the kidnappers are human, and using the captives as human prey for a twisted hunting expedition.
While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
As the Strike Team is preoccupied with gang violence, Kavanaugh decides to make the Barn his base of operations. An evasive serial killer from Dutch and Claudette’s past reenters their life. Meanwhile, additional strain is placed on their working relationship when Tina learns something personal about Julien.
Alan's friendly demeanor quickly turns into anger when a prestigious private school turns away a child prodigy because she lacks the face muscles to smile. Meanwhile, Shirley and Denise take on a hospital that refused to administer emergency birth control to a rape victim due to religious beliefs, and Brad is put on special assignment by Denny.
Debbie has a new best friend who is everything she wants to be and has the boys falling at her feet. Suddenly Debbie realises what other girls her own age have been getting up to and what she's been missing out on while left holding the fort at home. Sue disappears leaving Marty to deal with the debt collectors in the only way he knows how.
As Valentine's Day approaches, Kevin plans a special dinner, while Ruthie has a difficult time letting go of her feelings for Martin. Elsewhere, Annie has trouble accepting Rose---and the twins' request for a store-bought birthday cake instead of one made by her.
Mona fears that Chase hasn't made any special plans for Valentine's Day, so she tries to take action. Dee Dee sets Brett up on a blind date in the hopes of curing him of his bad mood concerning the holiday, which stems from a broken engagement. Spencer gets close with a rival music executive whom Mona despises. Adam grows irritated with his Valentine's date, a man with whom he's shared a yearly tryst for the past 10 years.
A sportscaster becomes a full-time dad when his ex-wife decides to accept a job out of the country and his teenage daughter, Breanna, moves in with him.
After Maya covers the bill for a pricey dinner, Darnell decides to pursue his dream career. William makes a mess when he pitches in with repairs.
When his mother's voice bleeds through from 2006 and he hears her say goodbye to him, Sam is desperate - he's alive and determined to make himself heard. But then the call comes in that a man has taken people hostage at the Manchester Gazette and is intent on killing them at 2pm - the same time Sam's machine will be switched off. Could stopping the hostage-taker be a way of staying alive?
Big pairs lead to one of the biggest coolers in history as Los Angeles Lakers owner Jerry Buss finds a win. High Stakes Poker continues with Daniel Negreanu, Barry Greenstein, Todd Brunson, Jennifer Harman, Eli Elezra, Shawn Sheikhan, and Sammy Farha.
Orel learns that God is present in everyone and everything. He ends up excusing himself from school, and going on a trip across town believing that he is able to stop people from sinning and heal them.
Jack poses as Rossler and manages to trace one of the canisters of nerve gas, but he goes against orders from the president when the terrorists target a shopping mall. Logan and Martha quarrel when she learns of her husband's intention to cover up the real reason for Walt's suicide.
Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.
Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse.
(Season Finale) The squad is assigned to protect a civilian convoy. Lt. Underpants leadership skills take a toll on the squad. Back at home, Bo meets somebody who may be able to help him get back in the Army and Sergio receives surprising news from Anna.
Lois discovers she has mono after a visit to the doctor. She then ends up giving it to Malcolm after her maternal instincts begin. As a result, both Lois and Malcolm are forced to spend an entire day and night together in the same room. Hal, meanwhile, is invited to all of his neighbors' parties after they know Lois will not be attending any of them.
Bette gives Tina her consent -- and a possible ultimatum -- to explore her feelings for men. Jenny meets with a publisher about her manuscript for a book, Billie makes Moira a tempting, but shady offer, Kit gives in to Angus' advances, and Carmen lays down the law to Shane regarding their relationship. Alice offers her support to Lara and celebrations are cut short when the girls finally find out the truth about Dana's condition.