J.D. develops a crush on a new physical therapist but due to his latest misfortunes, he finds it difficult to ask her out. Elliot asks Keith to move in with her, but is not willing to budge on her home rules. Turk breaks his arm and is sent back to residency by Dr. Kelso. Thanks to Dr. Cox, he realizes that he doesn't know as much about medicine as he thought.
The Cohen family says goodbye in the series finale as the episode jumps six months after the earthquake to show the Cohens, Ryan, Taylor, Summer and the Cooper women trying to piece their lives back together. The Cohens find out that fixing up their old mansion would cost more than rebuilding it but Ryan and Seth see this as an opportunity to give Sandy and an expecting Kirsten a surprise that'll change their lives.
With Joy now pregnant again, Earl looks back on her pregnancy during their marriage, and how his father was responsible for one of his first truly good deeds.
George has to take a pile of stuff down to the recycling center. He comes upon Steve who is holding Betsy's wagon. He has a package for Betsy that he is picking up from the package delivery right next door to the Recycling Center. George places all of his stuff in the wagon but, after an accident, one of the wagon's wheels pops off and Steve later winds up sending it rolling off on its own. With the wheel lost, Steve and George must find a new one that is the same size as all the others because, if one is used of the wrong size, the wagon does not travel straight.
A blizzard strands a family in the snow and Abby and Pratt quickly try to save the family. A gang shooting challenges Morris and Pratt. Meanwhile, Kovac and Abby begin making wedding plans, but their engagement might not be very secret; Gates struggles with the reappearance of his father and the possibility of losing Sarah; and Neela becomes jealous when Dubenko brings in a new surgical intern.
Jack sees an opportunity for budget cuts when Josh's contract is up, forcing Liz to go out of her way to motivate Josh into staying with TGS and not moving on to a rival show. Meanwhile, Kenneth earns a coveted spot in Tracy's entourage and Jenna gets in trouble over a misquote in Maxim.
On the way to Floaroma Town, Ash and the others hear some screaming nearby. At a house, a Pokémon hunter named J has just captured a girl named Melodi and kidnapped her Gardevoir and she quickly flees the scene. Ash gives chase to her, and tries to battle her, only to have Pikachu frozen in stone and stolen just like Gardevoir. They decide to help Officer Jenny and try to help capture J, but eventually she also gets Meowth as well! Before she can take off, Ash, Jessie, and James sneak under her vehicle and follow her to her secret flying base. Now, the reluctant allies must work together to get back their Pokémon from J's clutches.
OCC continues work on the chopper for the Flow International Corporation. Meanwhile, the crew goes to a paintball course to let off a little steam, OCC-style.
Allsion had a dream that takes place about 20 years in the future in which Marie dies of leukemia. Upon waking up Allison is determined to keep Marie safe no matter what needs to be done. Joe strongly disagrees with Allison's actions, and tries to convince her to stay rational. Meanwhile Scanlon investigates the sudden death of a close friend.
As Kate and Sawyer journey back to the main island with Karl, who is exhibiting effects of the brainwashing video, they argue over whether to go back and save Jack. On Hydra island, as Juliet's fate rests in his hands and a power struggle within the Others ensues, Jack recollects the time he spent in Phuket, Thailand and his relationship with Achara, a mysterious tattoo artist.
The lives of Jake and Hawkins are explored during this flashback episode. This episode begins 36 hours before the bombs went off. Sarah is introduced and is associated to Hawkins. Jake had been living in San Diego.
In Miami, Ricardo John catches his first case as lead detective: a young woman apparently raped and murdered in a vacant lot. In Dallas, Detectives Scott Sayers and Kenneth Penrod investigate a home invasion that left one man dead and his fianc e critically wounded. The case hangs on whether the surviving witness can identify her attackers.
It's Prom day, and emotions are flying high at Tree Hill. An emotional Haley confronts Nathan about the sex tape and asks for a list of all his past sexual encounters. Meanwhile, an angry Peyton asks Lucas to skip the dance altogether, but he refuses to take no for an answer. Finally, Brooke and Peyton let out all their tension in a confrontation that can tear them apart forever.
The BAU travels to Houston to investigate a series of murders that have occurred near construction sites and abandoned buildings. Because the murders appear to be random, the team believes the killer could be a homeless person. Meanwhile, everyone is noticing an apparent change in Reid's behavior.
Danny and Mac have to go to Noah’s Ark to find out if a broken promise leads to his murder. Stella and Sheldon investigate the death of a man dressed as a cigarette. Stella hopes to have her job after not telling Mac that she may be HIV right away.
After Julie reveals to Matt that she wants to have sex with him, Matt feels the need to put together something special. Tim clashes with his father.The Panthers are into the next round of the playoffs and looking solid.
In this special reunion episode, the beauties and the geeks are reunited in New York, where they reminisce about their good and bad times in the competition, new never-before-seen footage is revealed, and updates on the lives of the contestants are shared.
George, upset about being publicly humiliated at work, downs a shot of liquor along with the worm in it and hallucinates that he and Ernie are gay and about to be married to each other.
George has been hearing some strange noises from the neighbor's apartment upstairs. He figures that if The Man with the Yellow Hat lives with him, why wouldn't their new neighbor? But The Man is determined not to let George spy on the new neighbor to find out. George guesses that with a loud noise like the one he is hearing, the new neighbor has an elephant. But then George hears some different noises. What is that neighbor's elephant up to now and how can George get The Man to believe that an elephant is living upstairs?
The Man with the Yellow Hat has a hobby playing the tuba in Rescue Squad 86's firehouse band. George becomes excited at the thought of a band, but the Man will not let George play his tuba. George then decides to make his own instruments and that his animal friends will be the ones playing them. The only problem is that his animal friends seem to get distracted too easily and, after causing a loud racket on the roof of the apartment building where they are practicing, someone calls the fire department.